Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizer: Evidence of a safer cardiac profile of (R)-methadone
Published inPharmacopsychiatry, vol. 41, p. 207-208
Publication date2008
Abstract
Keywords
- Adult
- Alleles
- Analgesics, Opioid/blood/chemistry/*pharmacology
- Aryl Hydrocarbon Hydroxylases/*metabolism
- DNA, Complementary/biosynthesis/genetics
- Electrocardiography/drug effects
- Ether-A-Go-Go Potassium Channels/*drug effects
- Female
- Genotype
- Heart Rate/drug effects
- Humans
- Kinetics
- Long QT Syndrome/*chemically induced/*genetics/physiopathology
- Male
- Methadone/blood/chemistry/*pharmacology
- Middle Aged
- Oxidoreductases, N-Demethylating/*metabolism
- Patch-Clamp Techniques
- Potassium Channel Blockers
- Reverse Transcriptase Polymerase Chain Reaction
- Stereoisomerism
Affiliation entities
Citation (ISO format)
EAP, Chin Bin et al. Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizer: Evidence of a safer cardiac profile of (R)-methadone. In: Pharmacopsychiatry, 2008, vol. 41, p. 207–208. doi: 10.1055/s-0028-1088244
Main files (1)
Article (Published version)
Identifiers
- PID : unige:4087
- DOI : 10.1055/s-0028-1088244
Journal ISSN0176-3679