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Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure

Published inRespiratory research, vol. 15, 81
Publication date2014
Abstract

Hyperoxia exposure leads to the development of lung injury and bronchial hyperreactivity (BHR) via involvement of nitric oxide (NO) pathway. We aimed at characterizing whether the stimulation of the NO pathway by sildenafil or vasoactive intestinal peptide (VIP) is able to prevent the hyperoxia-induced development of BHR. The respective roles of the preserved lung volume and alveolar architecture, the anti-inflammatory and anti-apoptotic potentials of these treatments in the diminished lung responsiveness were also characterized.

Citation (ISO format)
CZOVEK, Dorottya et al. Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure. In: Respiratory research, 2014, vol. 15, p. 81. doi: 10.1186/1465-9921-15-81
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ISSN of the journal1465-9921
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Technical informations

Creation09/30/2014 12:05:00 PM
First validation09/30/2014 12:05:00 PM
Update time03/14/2023 9:50:32 PM
Status update03/14/2023 9:50:32 PM
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