UNIGE document Scientific Article
previous document  unige:40834  next document
add to browser collection
Title

Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure

Authors
Published in Respiratory Research. 2014, vol. 15, p. 81
Abstract Hyperoxia exposure leads to the development of lung injury and bronchial hyperreactivity (BHR) via involvement of nitric oxide (NO) pathway. We aimed at characterizing whether the stimulation of the NO pathway by sildenafil or vasoactive intestinal peptide (VIP) is able to prevent the hyperoxia-induced development of BHR. The respective roles of the preserved lung volume and alveolar architecture, the anti-inflammatory and anti-apoptotic potentials of these treatments in the diminished lung responsiveness were also characterized.
Identifiers
PMID: 25117627
Full text
Article (Published version) (3.3 MB) - public document Free access
Structures
Research groups Groupe Pache Jean-Claude (pathologie clinique) (658)
Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme (182)
Enfants et hyperréactivité bronchique (69)
Citation
(ISO format)
CZOVEK, Dorottya et al. Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure. In: Respiratory Research, 2014, vol. 15, p. 81. https://archive-ouverte.unige.ch/unige:40834

261 hits

64 downloads

Update

Deposited on : 2014-10-13

Export document
Format :
Citation style :