Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure

Article Article scientifique Article Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure eng 2014 author Czovek Dorottya 758823 author Petak Ferenc 133325 author Donati Yves Richard 24165 author Belin Xavier 0009-0007-1468-2793 690892 author Pache Jean-Claude 513830 author Barazzone Constance 29124 author Habre Walid 133724 81 10.1186/1465-9921-15-81 25117627 1465-9921 PMC4261898 https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-15-81 Hyperoxia exposure leads to the development of lung injury and bronchial hyperreactivity (BHR) via involvement of nitric oxide (NO) pathway. We aimed at characterizing whether the stimulation of the NO pathway by sildenafil or vasoactive intestinal peptide (VIP) is able to prevent the hyperoxia-induced development of BHR. The respective roles of the preserved lung volume and alveolar architecture, the anti-inflammatory and anti-apoptotic potentials of these treatments in the diminished lung responsiveness were also characterized. Animals Bronchial Hyperreactivity / pathology Bronchial Hyperreactivity / physiopathology Bronchial Hyperreactivity / prevention & control Hyperoxia / pathology Hyperoxia / physiopathology Hyperoxia / prevention & control Lung / drug effects Lung / physiology Male Piperazines / pharmacology Piperazines / therapeutic use Purines / pharmacology Purines / therapeutic use Rats Rats, Sprague-Dawley Sildenafil Citrate Sulfonamides / pharmacology Sulfonamides / therapeutic use Vasoactive Intestinal Peptide / pharmacology Vasoactive Intestinal Peptide / therapeutic use Dewey 616.07 Dewey 617 Dewey 618 Swiss National Science Foundation The Evolving Concept of Neuro-immune Interactions in the Development of Lung Function Impariment Following Allergen Exposure 143331 CH Projects Hungarian Basic Research Foundation OTKA K81179 and TÁMOP 4.2.2.A-11/1/KONV-2012-0052. 137 Département de pathologie et immunologie 21F 58 Département de pédiatrie, gynécologie et obstétrique 223 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 46 Enfants et hyperréactivité bronchique 69 148 Facteurs influençants le développement pulmonaire: étude translationnelle chez l'animal et l'homme 182 392 Groupe Pache Jean-Claude (pathologie clinique) 658 c65ba1f8-e38c-47fb-b340-4304083b39cd Laboratory of perioperative experimental pathology Respiratory research 15 62f69207-e76c-4ca1-b353-971be289be97 Article (Published version) Public Pache.pdf 3445431 application/pdf CC BY-2.0 openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Title	Published in	Year	Views	Downloads

Fluid replacement and respiratory function: comparison of whole blood with colloid and crystalloid: A randomised animal study	European journal of anaesthesiology	2016	548	0
Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure	Respiratory research	2014	674	217

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Czovek, Dorottya