UNIGE document Scientific Article
previous document  unige:40814  next document
add to browser collection

Positron-emission tomography imaging of early events after transplantation of islets of Langerhans

Authors show hidden authors show all authors [1 - 11]
Published in Transplantation. 2005, vol. 79, no. 3, p. 353-5
Abstract The aim of our study was to assess cell trafficking and early events after intraportal islet transplantation. Sprague-Dawley rat islets were incubated for various times, with various concentrations of 2-[F]fluoro-2deoxy-D-glucose (FDG), and in presence of various glucose concentrations. FDG-labeled syngeneic islets or FDG alone were injected in rats. Radioactivity was measured in the liver and in various organs by positron-emission tomography for 6 hours. FDG uptake increased with incubation time or FDG concentration and decreased in presence of glucose. In vivo, all islets implanted in the liver, with an uptake 4.4 times higher than controls (44.2% vs. 10.1%, P=0.02). Radioactivity in the liver decreased at the same rate after injection of labeled-islets and FDG alone. Ex vivo labeling of islets and imaging of posttransplant early events were feasible. Islets engrafted exclusively in the liver. No islet loss could be demonstrated 6 hours after transplantation.
Keywords AnimalsFluorodeoxyglucose F18/diagnostic use/pharmacokineticsIslets of Langerhans/radionuclide imagingIslets of Langerhans Transplantation/physiologyMalePositron-Emission TomographyRadiopharmaceuticals/diagnostic use/pharmacokineticsRatsRats, Sprague-DawleyTissue Distribution
PMID: 15699768
Full text
Article (Published version) (320 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
Cultures cellulaires et transplantations (519)
La transplantation d'îlots de Langerhans (623)
(ISO format)
TOSO, Christian et al. Positron-emission tomography imaging of early events after transplantation of islets of Langerhans. In: Transplantation, 2005, vol. 79, n° 3, p. 353-5. https://archive-ouverte.unige.ch/unige:40814

561 hits

0 download


Deposited on : 2014-10-09

Export document
Format :
Citation style :