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Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship

Boumendjel, Ahcène
Blanc, Madeleine
Geze, Annabelle
Choisnard, Luc
Wouessidjewe, Denis
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Published in Journal of Medicinal Chemistry. 2008, vol. 51, no. 7, p. 2307-10
Abstract A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation.
Keywords AnimalsAntimitotic Agents/chemistry/pharmacology/toxicityAntineoplastic Agents/chemistry/pharmacology/toxicityCell Cycle/drug effectsCell Line, TumorCell Proliferation/drug effectsCell Survival/drug effectsChalcones/chemistry/pharmacology/toxicityDrug Screening Assays, AntitumorDrug ToxicityHumansMiceMolecular StructureStereoisomerismStructure-Activity RelationshipSurvival Rate
PMID: 18293907
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BOUMENDJEL, Ahcène et al. Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship. In: Journal of Medicinal Chemistry, 2008, vol. 51, n° 7, p. 2307-10. doi: 10.1021/jm0708331 https://archive-ouverte.unige.ch/unige:4072

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Deposited on : 2009-11-20

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