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Scientific article
English

Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship

Published inJournal of medicinal chemistry, vol. 51, no. 7, p. 2307-2310
Publication date2008
Abstract

A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation.

Keywords
  • Animals
  • Antimitotic Agents/chemistry/pharmacology/toxicity
  • Antineoplastic Agents/chemistry/pharmacology/toxicity
  • Cell Cycle/drug effects
  • Cell Line, Tumor
  • Cell Proliferation/drug effects
  • Cell Survival/drug effects
  • Chalcones/chemistry/pharmacology/toxicity
  • Drug Screening Assays, Antitumor
  • Drug Toxicity
  • Humans
  • Mice
  • Molecular Structure
  • Stereoisomerism
  • Structure-Activity Relationship
  • Survival Rate
Citation (ISO format)
BOUMENDJEL, Ahcène et al. Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship. In: Journal of medicinal chemistry, 2008, vol. 51, n° 7, p. 2307–2310. doi: 10.1021/jm0708331
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Article (Published version)
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Identifiers
ISSN of the journal0022-2623
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