Active-site inactivated FVIIa decreases thrombosis and necrosis in a random skin flap model of acute ischemia

Alizadeh, Navid; Pittet Cuenod, Brigitte Maud; Tenorio, Xavier; Pyke, Charles; Baetens Baumann, Danielle; Schlaudraff, Kai-Uwe; Montandon, Denys; Ezban, Mirella; Pepper, Michael Sean

doi:10.1016/j.jss.2004.06.014

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Title		Active-site inactivated FVIIa decreases thrombosis and necrosis in a random skin flap model of acute ischemia
Authors		Alizadeh, Navid Pittet Cuenod, Brigitte Maud Tenorio, Xavier Pyke, Charles Baetens Baumann, Danielle Schlaudraff, Kai-Uwe Montandon, Denys Ezban, Mirella Pepper, Michael Sean show all authors [1 - 9]
Published in		Journal of Surgical Research. 2004, vol. 122, no. 2, p. 263-73
Abstract		Previous studies have emphasized the role of ischemia in inducing vascular thrombosis.
Keywords		Acute Disease — Animals — Blood Coagulation/drug effects — Factor VIIa/pharmacology — Female — Ischemia/complications/metabolism/pathology/physiopathology — Necrosis — Rats — Rats, Wistar — Regional Blood Flow — Skin/blood supply/metabolism/pathology — Surgical Flaps/pathology — Thromboplastin/antagonists & inhibitors/metabolism — Thrombosis/etiology/pathology — Time Factors — Tissue Survival/drug effects
Identifiers		DOI: 10.1016/j.jss.2004.06.014 PMID: 15555627
Full text		Article (Published version) (681 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research group		Groupe Pittet Cuenod Brigitte (chirurgie plastique et reconstructive) (96)
Citation (ISO format)		ALIZADEH, Navid et al. Active-site inactivated FVIIa decreases thrombosis and necrosis in a random skin flap model of acute ischemia. In: Journal of Surgical Research, 2004, vol. 122, n° 2, p. 263-73. doi: 10.1016/j.jss.2004.06.014 https://archive-ouverte.unige.ch/unige:40465