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Scientific article
English

PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse

Contributors

Peeters, H; Debeer, P; Bairoch, Amos Marc; Wilquet, V; Huysmans, C; Parthoens, E; Fryns, Jean-Pierre; Gewillig, M; Nakamura, Y; Niikawa, N; Van de Ven, W; Devriendt, Koenraad

Published in

Human genetics, vol. 112, no. 5-6, p. 573-580

Publication date

2003

Abstract

Heterotaxia is an aetiologically heterogeneous condition caused by an abnormal left-right axis formation, resulting in reversed left-right polarity of one or more organ systems. In a patient with heterotaxia and a de novo reciprocal translocation t(6;18)(q21;q21), we found that the PA26 gene was disrupted by the 6q21 breakpoint. Northern blot analysis showed decreased expression of the PA26 gene in an Epstein-Barr virus-transformed cell line of this patient. During early embryogenesis of Xenopus, the orthologue of PA26, XPA26 is exclusively expressed in the notochord, a midline structure. This further supports a possible role of PA26 in human situs determination. Mutation analysis of human PA26 gene in 40 unrelated individuals with unexplained heterotaxia failed to identify mutations, indicating that PA26 mutations are not a frequent cause of heterotaxia in humans. Analysis of the PA26 gene structure resulted in the identification of a novel PA26-related gene family, which we have named the sestrin family, and which comprises three closely related genes in human and in mouse.

Keywords

  • Animals
  • Chromosomes, Human, Pair 6
  • DNA Mutational Analysis
  • Heat-Shock Proteins
  • Humans
  • Mice
  • Multigene Family
  • Physical Chromosome Mapping
  • Proteins/genetics/metabolism
  • Situs Inversus/genetics
  • Translocation, Genetic

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

PEETERS, H et al. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. In: Human genetics, 2003, vol. 112, n° 5-6, p. 573–580. doi: 10.1007/s00439-003-0917-5

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

http://link.springer.com/article/10.1007/s00439-003-0917-5

Journal ISSN

0340-6717
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Technical informations

Creation

08/08/2014 09:50:00

First validation

08/08/2014 09:50:00

Update

30/03/2023 10:26:04

Status update

30/03/2023 10:26:03

Last indexation

30/10/2024 20:05:57
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