PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse

Peeters, H; Debeer, P; Bairoch, Amos Marc; Wilquet, V; Huysmans, C; Parthoens, E; Fryns, Jean-Pierre; Gewillig, M; Nakamura, Y; Niikawa, N; Van de Ven, W; Devriendt, Koenraad

doi:10.1007/s00439-003-0917-5

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Title		PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse
Authors		Peeters, H Debeer, P Bairoch, Amos Marc Wilquet, V Huysmans, C Parthoens, E Fryns, Jean-Pierre Gewillig, M Nakamura, Y Niikawa, N Van de Ven, W Devriendt, Koenraad show all authors [1 - 12]
Published in		Human Genetics. 2003, vol. 112, no. 5-6, p. 573-80
Abstract		Heterotaxia is an aetiologically heterogeneous condition caused by an abnormal left-right axis formation, resulting in reversed left-right polarity of one or more organ systems. In a patient with heterotaxia and a de novo reciprocal translocation t(6;18)(q21;q21), we found that the PA26 gene was disrupted by the 6q21 breakpoint. Northern blot analysis showed decreased expression of the PA26 gene in an Epstein-Barr virus-transformed cell line of this patient. During early embryogenesis of Xenopus, the orthologue of PA26, XPA26 is exclusively expressed in the notochord, a midline structure. This further supports a possible role of PA26 in human situs determination. Mutation analysis of human PA26 gene in 40 unrelated individuals with unexplained heterotaxia failed to identify mutations, indicating that PA26 mutations are not a frequent cause of heterotaxia in humans. Analysis of the PA26 gene structure resulted in the identification of a novel PA26-related gene family, which we have named the sestrin family, and which comprises three closely related genes in human and in mouse.
Keywords		Animals — Chromosomes, Human, Pair 6 — DNA Mutational Analysis — Heat-Shock Proteins — Humans — Mice — Multigene Family — Physical Chromosome Mapping — Proteins/genetics/metabolism — Situs Inversus/genetics — Translocation, Genetic
Identifiers		DOI: 10.1007/s00439-003-0917-5 PMID: 12607115
Full text		Article (Published version) (999 Kb) - Limited access to UNIGE Other version: http://link.springer.com/article/10.1007/s00439-003-0917-5
Structures		Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research groups		Calipho (80) Swiss-Prot Research Group Swiss Institute of Bioinformatics
Citation (ISO format)		PEETERS, H et al. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. In: Human Genetics, 2003, vol. 112, n° 5-6, p. 573-80. doi: 10.1007/s00439-003-0917-5 https://archive-ouverte.unige.ch/unige:40338