β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment

Halban, Philippe A.; Polonsky, Kenneth S; Bowden, Donald W; Hawkins, Meredith A; Ling, Charlotte; Mather, Kieren J; Powers, Alvin C; Rhodes, Christopher J; Sussel, Lori; Weir, Gordon C

doi:10.1210/jc.2014-1425

Professional article

English

β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment

ContributorsHalban, Philippe A.; Polonsky, Kenneth S; Bowden, Donald W; Hawkins, Meredith A; Ling, Charlotte; Mather, Kieren J; Powers, Alvin C; Rhodes, Christopher J; Sussel, Lori; Weir, Gordon C

Published inThe Journal of clinical endocrinology and metabolism, vol. 99, no. 6, p. 1983-1992

Publication date2014

Abstract

This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment.

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

Research groups

Fonction de l'îlot de Langerhans (324)

Citation (ISO format)

HALBAN, Philippe A. et al. β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. In: The Journal of clinical endocrinology and metabolism, 2014, vol. 99, n° 6, p. 1983–1992. doi: 10.1210/jc.2014-1425

Article (Accepted version)

Identifiers

PID : unige:40332
DOI : 10.1210/jc.2014-1425
PMID : 24712577

Journal ISSN0021-972X

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β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment

This article examines the foundation of β-cell failure in type 2 diabetes (T2D) and suggests areas for future research on the underlying mechanisms that may lead to improved prevention and treatment.

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