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Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers |
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Published in | Investigative radiology. 2005, vol. 40, no. 4, p. 187-94 | |
Abstract | During biliary cirrhosis in rats, organic anion-transporting peptides (Oatps) and ATP-dependent multidrug resistance-associated protein 2 (Mrp2) that are likely to transport the contrast agent Gd-BOPTA through hepatocytes are down-regulated. However, the consequences of such down-regulation on the signal intensity (SI) enhancement are unknown. Consequently, the aim of our study was to measure the hepatic SI enhancement during Gd-BOPTA perfusion as well as the Oatp and Mrp2 expression in normal and cirrhotic livers. | |
Keywords | ATP-Binding Cassette Transporters/analysis — Albumins/analysis — Animals — Bile Ducts/physiology — Blotting, Western — Contrast Media — Keratins/analysis — Liver Cirrhosis, Experimental/diagnosis — Magnetic Resonance Imaging — Meglumine/analogs & derivatives/diagnostic use — Organic Anion Transporters/analysis — Organometallic Compounds/diagnostic use — Perfusion — Rats — Rats, Sprague-Dawley | |
Identifiers | PMID: 15770136 | |
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Research groups | Imagerie cardiaque fonctionnelle (541) Pharmacologie et imagerie du foie (664) | |
Citation (ISO format) | PLANCHAMP MESSEILLER, Corinne et al. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. In: Investigative radiology, 2005, vol. 40, n° 4, p. 187-94. https://archive-ouverte.unige.ch/unige:40298 |