Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers

Planchamp Messeiller, Corinne; Montet, Xavier Cédric Rodolphe; Frossard, Jean-Louis; Quadri Defilippis, Rafael; Stieger, Bruno; Meier, Peter J; Ivancevic, Marko Kresimir; Vallée, Jean-Paul; Terrier, François; Pastor, Catherine

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Title		Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers
Authors		Planchamp Messeiller, Corinne Montet, Xavier Cédric Rodolphe Frossard, Jean-Louis Quadri Defilippis, Rafael Stieger, Bruno Meier, Peter J Ivancevic, Marko Kresimir Vallée, Jean-Paul Terrier, François Pastor, Catherine show all authors [1 - 10]
Published in		Investigative Radiology. 2005, vol. 40, no. 4, p. 187-94
Abstract		During biliary cirrhosis in rats, organic anion-transporting peptides (Oatps) and ATP-dependent multidrug resistance-associated protein 2 (Mrp2) that are likely to transport the contrast agent Gd-BOPTA through hepatocytes are down-regulated. However, the consequences of such down-regulation on the signal intensity (SI) enhancement are unknown. Consequently, the aim of our study was to measure the hepatic SI enhancement during Gd-BOPTA perfusion as well as the Oatp and Mrp2 expression in normal and cirrhotic livers.
Keywords		ATP-Binding Cassette Transporters/analysis — Albumins/analysis — Animals — Bile Ducts/physiology — Blotting, Western — Contrast Media — Keratins/analysis — Liver Cirrhosis, Experimental/diagnosis — Magnetic Resonance Imaging — Meglumine/analogs & derivatives/diagnostic use — Organic Anion Transporters/analysis — Organometallic Compounds/diagnostic use — Perfusion — Rats — Rats, Sprague-Dawley
Identifiers		PMID: 15770136
Full text		Article (Published version) (1.5 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research groups		Pharmacologie et imagerie du foie (664) Imagerie cardiaque fonctionnelle (541)
Citation (ISO format)		PLANCHAMP MESSEILLER, Corinne et al. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. In: Investigative Radiology, 2005, vol. 40, n° 4, p. 187-94. https://archive-ouverte.unige.ch/unige:40298