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Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers

Stieger, Bruno
Meier, Peter J
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Published in Investigative radiology. 2005, vol. 40, no. 4, p. 187-94
Abstract During biliary cirrhosis in rats, organic anion-transporting peptides (Oatps) and ATP-dependent multidrug resistance-associated protein 2 (Mrp2) that are likely to transport the contrast agent Gd-BOPTA through hepatocytes are down-regulated. However, the consequences of such down-regulation on the signal intensity (SI) enhancement are unknown. Consequently, the aim of our study was to measure the hepatic SI enhancement during Gd-BOPTA perfusion as well as the Oatp and Mrp2 expression in normal and cirrhotic livers.
Keywords ATP-Binding Cassette Transporters/analysisAlbumins/analysisAnimalsBile Ducts/physiologyBlotting, WesternContrast MediaKeratins/analysisLiver Cirrhosis, Experimental/diagnosisMagnetic Resonance ImagingMeglumine/analogs & derivatives/diagnostic useOrganic Anion Transporters/analysisOrganometallic Compounds/diagnostic usePerfusionRatsRats, Sprague-Dawley
PMID: 15770136
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Research groups Imagerie cardiaque fonctionnelle (541)
Pharmacologie et imagerie du foie (664)
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PLANCHAMP MESSEILLER, Corinne et al. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. In: Investigative radiology, 2005, vol. 40, n° 4, p. 187-94. https://archive-ouverte.unige.ch/unige:40298

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Deposited on : 2014-09-18

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