UNIGE document Scientific Article
previous document  unige:40294  next document
add to browser collection
Title

Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver

Authors
Published in Applied Radiation and Isotopes. 2005, vol. 62, no. 6, p. 943-9
Abstract The aim was to study the influence of temperature on the transport of the hepatobiliary contrast agent Gadobenate dimeglumine (Gd-BOPTA). Rat livers were isolated and perfused with Gd-BOPTA at 12, 25, 30, 36 and 38 degrees C. After the perfusion period, biopsies were collected and the MR signal intensity was measured. Uptake and biliary excretion were quantified with radiolabeled Gd-BOPTA. MR signal intensity decreased with temperature of perfusion. This phenomenon was appropriately quantified with 153Gd and 153Sm labeling, in contrast to 67Ga.
Keywords AnimalsContrast Media/pharmacokineticsLiver/metabolismMeglumine/analogs & derivatives/pharmacokineticsOrganometallic Compounds/pharmacokineticsRatsRats, Sprague-DawleyTemperature
Identifiers
PMID: 15799874
Full text
Article (Published version) (229 Kb) - public document Free access
Structures
Research group Pharmacologie et imagerie du foie (664)
Citation
(ISO format)
PLANCHAMP MESSEILLER, Corinne et al. Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver. In: Applied Radiation and Isotopes, 2005, vol. 62, n° 6, p. 943-9. https://archive-ouverte.unige.ch/unige:40294

176 hits

51 downloads

Update

Deposited on : 2014-09-18

Export document
Format :
Citation style :