Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver

Planchamp Messeiller, Corinne; Beyer, Gerd-Jurgen; Slosman, Daniel; Terrier, François; Pastor, Catherine

doi:10.1016/j.apradiso.2004.11.002

Scientific article

English

Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver

ContributorsPlanchamp Messeiller, Corinne; Beyer, Gerd-Jurgen; Slosman, Daniel; Terrier, François; Pastor, Catherine

Published inApplied radiation and isotopes, vol. 62, no. 6, p. 943-949

Publication date2005

Abstract

The aim was to study the influence of temperature on the transport of the hepatobiliary contrast agent Gadobenate dimeglumine (Gd-BOPTA). Rat livers were isolated and perfused with Gd-BOPTA at 12, 25, 30, 36 and 38 degrees C. After the perfusion period, biopsies were collected and the MR signal intensity was measured. Uptake and biliary excretion were quantified with radiolabeled Gd-BOPTA. MR signal intensity decreased with temperature of perfusion. This phenomenon was appropriately quantified with 153Gd and 153Sm labeling, in contrast to 67Ga.

Keywords

Animals
Contrast Media/pharmacokinetics
Liver/metabolism
Meglumine/analogs & derivatives/pharmacokinetics
Organometallic Compounds/pharmacokinetics
Rats
Rats, Sprague-Dawley
Temperature

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Research groups

Pharmacologie et imagerie du foie (664)

Citation (ISO format)

PLANCHAMP MESSEILLER, Corinne et al. Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver. In: Applied radiation and isotopes, 2005, vol. 62, n° 6, p. 943–949. doi: 10.1016/j.apradiso.2004.11.002

Article (Published version)

Identifiers

PID : unige:40294
DOI : 10.1016/j.apradiso.2004.11.002
PMID : 15799874

ISSN of the journal0969-8043

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Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver

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