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Scientific article
Open access
English

Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver

Published inApplied radiation and isotopes, vol. 62, no. 6, p. 943-949
Publication date2005
Abstract

The aim was to study the influence of temperature on the transport of the hepatobiliary contrast agent Gadobenate dimeglumine (Gd-BOPTA). Rat livers were isolated and perfused with Gd-BOPTA at 12, 25, 30, 36 and 38 degrees C. After the perfusion period, biopsies were collected and the MR signal intensity was measured. Uptake and biliary excretion were quantified with radiolabeled Gd-BOPTA. MR signal intensity decreased with temperature of perfusion. This phenomenon was appropriately quantified with 153Gd and 153Sm labeling, in contrast to 67Ga.

Keywords
  • Animals
  • Contrast Media/pharmacokinetics
  • Liver/metabolism
  • Meglumine/analogs & derivatives/pharmacokinetics
  • Organometallic Compounds/pharmacokinetics
  • Rats
  • Rats, Sprague-Dawley
  • Temperature
Citation (ISO format)
PLANCHAMP MESSEILLER, Corinne et al. Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver. In: Applied radiation and isotopes, 2005, vol. 62, n° 6, p. 943–949. doi: 10.1016/j.apradiso.2004.11.002
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Article (Published version)
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ISSN of the journal0969-8043
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