Quantification of Gd-BOPTA uptake and biliary excretion from dynamic magnetic resonance imaging in rat livers: model validation with 153Gd-BOPTA

Planchamp, Corinne; Pastor, Catherine; Balant, Luc; Becker, Christoph; Terrier, François; Gex-Fabry, Marianne

doi:10.1097/01.rli.0000183053.08921.2b

Scientific article

English

Quantification of Gd-BOPTA uptake and biliary excretion from dynamic magnetic resonance imaging in rat livers: model validation with 153Gd-BOPTA

ContributorsPlanchamp, Corinne; Pastor, Catherine

; Balant, Luc; Becker, Christoph; Terrier, François; Gex-Fabry, Marianne

Published inInvestigative radiology, vol. 40, no. 11, p. 705-714

Publication date2005

Abstract

We sought to develop and validate a pharmacokinetic model allowing description of the magnetic resonance (MR) signal intensity induced by the hepatobiliary contrast agent Gd-BOPTA and to quantify the overall Gd-BOPTA transport in rat liver.

Keywords

Animals
Bile/metabolism
Biological Transport
Contrast Media/pharmacokinetics
Extracellular Space/metabolism
Gadolinium DTPA/pharmacokinetics
Liver/metabolism
Magnetic Resonance Imaging
Meglumine/analogs & derivatives/pharmacokinetics
Models, Biological
Organometallic Compounds/pharmacokinetics
Perfusion
Rats
Rats, Sprague-Dawley
Reproducibility of Results

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Research groups

Pharmacologie et imagerie du foie (664)

Funding

Swiss National Science Foundation - 3200-100868

Citation (ISO format)

PLANCHAMP, Corinne et al. Quantification of Gd-BOPTA uptake and biliary excretion from dynamic magnetic resonance imaging in rat livers: model validation with 153Gd-BOPTA. In: Investigative radiology, 2005, vol. 40, n° 11, p. 705–714. doi: 10.1097/01.rli.0000183053.08921.2b

Article (Published version)

Identifiers

PID : unige:40291
DOI : 10.1097/01.rli.0000183053.08921.2b
PMID : 16230903

Journal ISSN0020-9996

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Quantification of Gd-BOPTA uptake and biliary excretion from dynamic magnetic resonance imaging in rat livers: model validation with 153Gd-BOPTA

We sought to develop and validate a pharmacokinetic model allowing description of the magnetic resonance (MR) signal intensity induced by the hepatobiliary contrast agent Gd-BOPTA and to quantify the overall Gd-BOPTA transport in rat liver.

Technical informations