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Title

The importance of regulatory RNAs in Staphylococcus aureus

Authors
Tomasini, Arnaud
Fechter, Pierre
Romby, Pascale
Caldelari, Isabelle
Published in Infection, Genetics and Evolution. 2014, vol. 21, p. 616-26
Abstract RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence.
Identifiers
PMID: 24291227
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Article (Published version) (1.3 MB) - public document Free access
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Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
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TOMASINI, Arnaud et al. The importance of regulatory RNAs in Staphylococcus aureus. In: Infection, Genetics and Evolution, 2014, vol. 21, p. 616-26. https://archive-ouverte.unige.ch/unige:40286

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Deposited on : 2014-09-18

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