UNIGE document Scientific Article
previous document  unige:40286  next document
add to browser collection

The importance of regulatory RNAs in Staphylococcus aureus

Tomasini, Arnaud
Fechter, Pierre
Romby, Pascale
Caldelari, Isabelle
Published in Infection, Genetics and Evolution. 2014, vol. 21, p. 616-26
Abstract RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence.
PMID: 24291227
Full text
Article (Published version) (1.3 MB) - public document Free access
Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
(ISO format)
TOMASINI, Arnaud et al. The importance of regulatory RNAs in Staphylococcus aureus. In: Infection, Genetics and Evolution, 2014, vol. 21, p. 616-26. doi: 10.1016/j.meegid.2013.11.016 https://archive-ouverte.unige.ch/unige:40286

454 hits



Deposited on : 2014-09-18

Export document
Format :
Citation style :