UNIGE document Scientific Article
previous document  unige:4004  next document
add to browser collection
Title

Physicochemical Profiling of Sartans: Detailed Study of Ionisation Constants and Distribution Coefficients
Authors
Tosco, Paolo
Rolando, Barbara
Fruttero, Roberta
Henchoz, Yveline
Martel, Sophie
Carrupt, Pierre-Alain
Gasco, Alberto
Published in Helvetica Chimica Acta. 2008, vol. 91, p. 468-482
Abstract A detailed investigation of the ionization and lipophilicity profiles of selected sartans (valsartan, losartan, irbesartan, candesartan, candesartan cilexetil), a class of antihypertensives commonly used in therapy, is presented. The pKa macroconstants were determined by integrated potentiometry, capillary electrophoresis, and UV spectrophotometry. The measured pKa macroconstants were connected with the ionizable centers present in each molecule with the aid of model compounds. Potentiometric titrations with the GLpKa apparatus were performed to determine the distribution profile (logD vs. pH) of valsartan, while the shake-flask procedure was used to characterize the distribution profile of the other compounds. Valsartan showed a lipophilicity profile consistent with the presence of two acidic centers. Losartan and irbesartan, which contain one acidic and one basic center, displayed the classical bellshaped profile of ordinary ampholytes. By contrast, a more complex situation emerged in the case of candesartan, due to the large number of ionization equilibria involved. The low solubility of candesartan cilexetil, together with the ease of hydrolysis of the ester moiety, prevented a successful investigation of its ionization and lipophilicity profiles.
Identifiers
Full text
Article (Published version) (337 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté des sciences / Section des sciences pharmaceutiques
Citation
(ISO format) 		TOSCO, Paolo et al. Physicochemical Profiling of Sartans: Detailed Study of Ionisation Constants and Distribution Coefficients. In: Helvetica Chimica Acta, 2008, vol. 91, p. 468-482. https://archive-ouverte.unige.ch/unige:4004

288 hits

1 download

Contact an author

Update request

Update

Deposited on : 2009-11-10

Export document
Format :
Citation style :