Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets

Mai, Gang; Bucher, Pascal Alain Robert; Morel, Philippe; Mei, Jie; Bosco, Domenico; Andres, Axel; Mathe, Z; Wekerle, T; Berney, Thierry; Buehler, Leo Hans

doi:10.1016/j.transproceed.2004.12.306

Scientific article

English

Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets

ContributorsMai, Gang; Bucher, Pascal Alain Robert; Morel, Philippe; Mei, Jie; Bosco, Domenico; Andres, Axel; Mathe, Z; Wekerle, T; Berney, Thierry; Buehler, Leo Hans

Published inTransplantation proceedings, vol. 37, no. 1, p. 460-462

Publication date2005

Abstract

Costimulatory blockade has been shown to allow long-term survival of xenogeneic islets. The aim of the present study was to evaluate the role of recipient CD40 and CD154 in the rejection process of concordant and discordant islet xenotransplantation (Tx).

Keywords

Animals
Antigens, CD40/genetics/physiology
CD40 Ligand/genetics/physiology
Gene Deletion
Graft Rejection/pathology
Humans
Islets of Langerhans Transplantation/pathology
Lymphocyte Culture Test, Mixed
Mice
Mice, Inbred C57BL
Mice, Knockout
Rats
Transplantation, Heterologous/pathology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Citation (ISO format)

MAI, Gang et al. Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets. In: Transplantation proceedings, 2005, vol. 37, n° 1, p. 460–462. doi: 10.1016/j.transproceed.2004.12.306

Article (Published version)

Identifiers

PID : unige:39999
DOI : 10.1016/j.transproceed.2004.12.306
PMID : 15808676

Journal ISSN0041-1345

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Role of CD40-CD154 pathway in the rejection of concordant and discordant xenogeneic islets

Costimulatory blockade has been shown to allow long-term survival of xenogeneic islets. The aim of the present study was to evaluate the role of recipient CD40 and CD154 in the rejection process of concordant and discordant islet xenotransplantation (Tx).

Technical informations