en
Scientific article
English

Adipose tissue is a regulated source of interleukin-10

Published inCytokine, vol. 29, no. 6, p. 270-274
Publication date2005
Abstract

White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase).

Keywords
  • Adipose Tissue/immunology/secretion
  • Animals
  • Gene Expression Regulation
  • Humans
  • Interleukin-10/biosynthesis/genetics/secretion
  • Mice
  • Mice, Inbred C57BL
  • Obesity/genetics/immunology
  • RNA, Messenger/biosynthesis
Citation (ISO format)
JUGE AUBRY, Cristiana et al. Adipose tissue is a regulated source of interleukin-10. In: Cytokine, 2005, vol. 29, n° 6, p. 270–274. doi: 10.1016/j.cyto.2004.10.017
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Article (Published version)
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Identifiers
ISSN of the journal1043-4666
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