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Adipose tissue is a regulated source of interleukin-10

Juge Aubry, Cristiana
Giusti, Vittorio
Published in Cytokine. 2005, vol. 29, no. 6, p. 270-4
Abstract White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase).
Keywords Adipose Tissue/immunology/secretionAnimalsGene Expression RegulationHumansInterleukin-10/biosynthesis/genetics/secretionMiceMice, Inbred C57BLObesity/genetics/immunologyRNA, Messenger/biosynthesis
PMID: 15749027
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Research group Groupe Pittet Cuenod Brigitte (chirurgie plastique et reconstructive) (96)
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JUGE AUBRY, Cristiana et al. Adipose tissue is a regulated source of interleukin-10. In: Cytokine, 2005, vol. 29, n° 6, p. 270-4. doi: 10.1016/j.cyto.2004.10.017 https://archive-ouverte.unige.ch/unige:39865

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Deposited on : 2014-09-01

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