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Edaravone derivatives containing NO-donor functions

Chegaev, Konstantin
Cena, Clara
Giorgis, Marta
Rolando, Barbara
Tosco, Paolo
Bertinaria, Massimo
Fruttero, Roberta
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Published in Journal of medicinal chemistry. 2009, vol. 52, no. 2, p. 574-8
Abstract A new series of polyvalent drugs obtained by joining edaravone with NO-donor moieties is described. All compounds display high antioxidant power together with NO-dependent vasodilator properties. The analysis of a number of molecular descriptors shows that the antioxidant activity, which is tightly linked to the presence of the edaravone substructure, is principally modulated by lipophilicity. These products are potentially useful in the treatment of cardiovascular disorders in which EDRF deficiency and ROS excess are involved.
Keywords Antioxidants/chemistry/pharmacologyAntipyrine/analogs & derivatives/chemistry/pharmacologyNitric Oxide Donors/chemistry/pharmacologyVasodilator Agents/chemistry/pharmacology
PMID: 19113954
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CHEGAEV, Konstantin et al. Edaravone derivatives containing NO-donor functions. In: Journal of medicinal chemistry, 2009, vol. 52, n° 2, p. 574-8. doi: 10.1021/jm8007008 https://archive-ouverte.unige.ch/unige:3985

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Deposited on : 2009-11-05

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