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Scientific article
English

Edaravone derivatives containing NO-donor functions

Contributors

Chegaev, Konstantin; Cena, Clara; Giorgis, Marta; Rolando, Barbara; Tosco, Paolo; Bertinaria, Massimo; Fruttero, Roberta; Carrupt, Pierre-Alain; Gasco, Alberto

Published in

Journal of medicinal chemistry, vol. 52, no. 2, p. 574-578

Publication date

2009

Abstract

A new series of polyvalent drugs obtained by joining edaravone with NO-donor moieties is described. All compounds display high antioxidant power together with NO-dependent vasodilator properties. The analysis of a number of molecular descriptors shows that the antioxidant activity, which is tightly linked to the presence of the edaravone substructure, is principally modulated by lipophilicity. These products are potentially useful in the treatment of cardiovascular disorders in which EDRF deficiency and ROS excess are involved.

Keywords

  • Antioxidants/chemistry/pharmacology
  • Antipyrine/analogs & derivatives/chemistry/pharmacology
  • Nitric Oxide Donors/chemistry/pharmacology
  • Vasodilator Agents/chemistry/pharmacology

UNIGE affiliation entities

Citation (ISO format)

CHEGAEV, Konstantin et al. Edaravone derivatives containing NO-donor functions. In: Journal of medicinal chemistry, 2009, vol. 52, n° 2, p. 574–578. doi: 10.1021/jm8007008

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0022-2623
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Technical informations

Creation

05/11/2009 12:03:00

First validation

05/11/2009 12:03:00

Update

26/03/2026 10:28:49

Status update

26/03/2026 10:28:49

Last indexation

26/03/2026 10:31:56
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