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Scientific article
English

Edaravone derivatives containing NO-donor functions

Published inJournal of medicinal chemistry, vol. 52, no. 2, p. 574-578
Publication date2009
Abstract

A new series of polyvalent drugs obtained by joining edaravone with NO-donor moieties is described. All compounds display high antioxidant power together with NO-dependent vasodilator properties. The analysis of a number of molecular descriptors shows that the antioxidant activity, which is tightly linked to the presence of the edaravone substructure, is principally modulated by lipophilicity. These products are potentially useful in the treatment of cardiovascular disorders in which EDRF deficiency and ROS excess are involved.

Keywords
  • Antioxidants/chemistry/pharmacology
  • Antipyrine/analogs & derivatives/chemistry/pharmacology
  • Nitric Oxide Donors/chemistry/pharmacology
  • Vasodilator Agents/chemistry/pharmacology
Citation (ISO format)
CHEGAEV, Konstantin et al. Edaravone derivatives containing NO-donor functions. In: Journal of medicinal chemistry, 2009, vol. 52, n° 2, p. 574–578. doi: 10.1021/jm8007008
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1520-4804
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Technical informations

Creation11/05/2009 12:03:00 PM
First validation11/05/2009 12:03:00 PM
Update time03/14/2023 3:17:14 PM
Status update03/14/2023 3:17:14 PM
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