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Scientific article
English

Lipophilicity of basic drugs measured by hydrophilic interaction chromatography

Published inJournal of medicinal chemistry, vol. 52, no. 10, p. 3416-3419
Publication date2009
Abstract

RPLC gains acceptance in pharmaceutical research for the rapid determination of lipophilicity but remains limited for the determination of partition coefficients of moderate to strong basic compounds under their neutral form because stationary phases are not compatible with high pH conditions. In this work, HILIC technique was used to accurately measure log P(oct) of the neutral form of basic drugs by measuring the difference between 2 isocratic log k values (Delta log k(0-95)) of their cationic form.

Keywords
  • Chemistry, Pharmaceutical/methods
  • Chromatography/methods
  • Hydrogen-Ion Concentration
  • Hydrophobicity
  • Pharmaceutical Preparations/chemistry
  • Solubility
  • Technology, Pharmaceutical/methods
Citation (ISO format)
BARD, Bruno, CARRUPT, Pierre-Alain, MARTEL, Sophie. Lipophilicity of basic drugs measured by hydrophilic interaction chromatography. In: Journal of medicinal chemistry, 2009, vol. 52, n° 10, p. 3416–3419. doi: 10.1021/jm9003945
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0022-2623
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Technical informations

Creation11/05/2009 11:21:00 AM
First validation11/05/2009 11:21:00 AM
Update time03/14/2023 3:17:13 PM
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