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Lipophilicity of basic drugs measured by hydrophilic interaction chromatography

Bard, Bruno
Published in Journal of Medicinal Chemistry. 2009, vol. 52, no. 10, p. 3416-9
Abstract RPLC gains acceptance in pharmaceutical research for the rapid determination of lipophilicity but remains limited for the determination of partition coefficients of moderate to strong basic compounds under their neutral form because stationary phases are not compatible with high pH conditions. In this work, HILIC technique was used to accurately measure log P(oct) of the neutral form of basic drugs by measuring the difference between 2 isocratic log k values (Delta log k(0-95)) of their cationic form.
Keywords Chemistry, Pharmaceutical/methodsChromatography/methodsHydrogen-Ion ConcentrationHydrophobicityPharmaceutical Preparations/chemistrySolubilityTechnology, Pharmaceutical/methods
PMID: 19397318
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BARD, Bruno, CARRUPT, Pierre-Alain, MARTEL, Sophie. Lipophilicity of basic drugs measured by hydrophilic interaction chromatography. In: Journal of Medicinal Chemistry, 2009, vol. 52, n° 10, p. 3416-9. doi: 10.1021/jm9003945 https://archive-ouverte.unige.ch/unige:3981

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Deposited on : 2009-11-05

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