Transplantation of discordant xenogeneic islets using repeated therapy with anti-CD154

Bucher, Pascal Alain Robert; Mai, Gang; Morel, Philippe; Mathe, Zoltan; Bosco, Domenico; Pernin, Nadine; Wekerle, Thomas; Berney, Thierry; Buehler, Leo Hans

doi:10.1097/01.tp.0000163505.63159.69

Scientific article

English

Transplantation of discordant xenogeneic islets using repeated therapy with anti-CD154

ContributorsBucher, Pascal Alain Robert; Mai, Gang; Morel, Philippe; Mathe, Zoltan; Bosco, Domenico; Pernin, Nadine; Wekerle, Thomas; Berney, Thierry; Buehler, Leo Hans

Published inTransplantation, vol. 79, no. 11, p. 1545-1552

Publication date2005

Abstract

Costimulatory blockade has been shown to allow long-term survival of xenogeneic islets. The aim of the present study was to analyze the possibility of xenogeneic islet retransplantation using costimulatory blockade.

Keywords

Animals
Antibodies, Monoclonal/therapeutic use
B-Lymphocytes/immunology
CD40 Ligand/immunology
Cricetinae
Diabetes Mellitus, Experimental/surgery
Glucagon/analysis
Graft Survival/immunology
Histocompatibility Testing
Humans
Insulin/analysis
Islets of Langerhans Transplantation/immunology/physiology
Male
Mice
Mice, Inbred C57BL
T-Lymphocytes/immunology
Tissue Donors
Transplantation, Heterologous/immunology/physiology

Affiliation

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research group

Citation (ISO format)

BUCHER, Pascal Alain Robert et al. Transplantation of discordant xenogeneic islets using repeated therapy with anti-CD154. In: Transplantation, 2005, vol. 79, n° 11, p. 1545–1552. doi: 10.1097/01.tp.0000163505.63159.69

Article (Published version)

Identifiers

PID : unige:39640
DOI : 10.1097/01.tp.0000163505.63159.69
PMID : 15940044

ISSN of the journal0041-1337

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Transplantation of discordant xenogeneic islets using repeated therapy with anti-CD154

Costimulatory blockade has been shown to allow long-term survival of xenogeneic islets. The aim of the present study was to analyze the possibility of xenogeneic islet retransplantation using costimulatory blockade.

Technical informations