UNIGE document Scientific Article
previous document  unige:39621  next document
add to browser collection
Title

Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells

Authors
Caille, Dorothée
Published in Diabetologia. 2005, vol. 48, no. 8, p. 1523-33
Abstract Alpha1-proteinase inhibitor (alpha1-PI) has been considered a key player in inflammatory processes. In humans, the main production site of alpha1-PI is the liver, but other tissues, including pancreatic islets, also synthesise this molecule. The aims of this study were to assess the islet cell types that produce alpha1-PI, to determine whether alpha1-PI is actually secreted by islet cells, and to assess how its production and/or secretion are regulated.
Keywords 1-Methyl-3-isobutylxanthine/pharmacologyAnti-Inflammatory Agents/pharmacologyAntibodies/pharmacologyBlotting, WesternCell SeparationCells, CulturedCytokines/pharmacologyDexamethasone/pharmacologyEnzyme-Linked Immunosorbent AssayFluorescent Antibody TechniqueHemolytic Plaque TechniqueHumansImmunohistochemistryInterleukin-1/pharmacologyIslets of Langerhans/drug effects/metabolismMicroscopy, ImmunoelectronAlpha 1-Antitrypsin/biosynthesis/genetics
Identifiers
PMID: 16001235
Full text
Article (Published version) (472 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Cultures cellulaires et transplantations (519)
Chirurgie viscérale (104)
Transplantation et hépatologie (905)
La transplantation d'îlots de Langerhans (623)
Citation
(ISO format)
BOSCO, Domenico et al. Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells. In: Diabetologia, 2005, vol. 48, n° 8, p. 1523-33. https://archive-ouverte.unige.ch/unige:39621

181 hits

0 download

Update

Deposited on : 2014-08-21

Export document
Format :
Citation style :