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Ostéonécrose des maxillaires et bisphosphonates

Published in Revue médicale suisse. 2005, vol. 1, no. 39, p. 2537-40,2542-3
Abstract Widely prescribed, bisphosphonates inhibit bone resorption. They are not metabolised and have long half-lives. Two cases of osteonecrosis of the jaws have recently been attributed to bisphosphonates at the University Hospital of Geneva. The recent literature reveals more than a hundred similar cases throughout the world. Bone exposure appears spontaneously or after dental care. Treatment of the osteonecrosis is controversial and cure very difficult. This pathology is usually seen in patients on chemotherapy, steroids and i.v. bisphosphonates, but is sometimes seen with low-dose p.o. bisphosphonates. In view of the strong association between bisphosphonate therapy and osteonecrosis of the jaw, specialists have recommended dental and oral evaluation during bisphosphonate therapy as well as for several years after drug discontinuation.
Keywords Age FactorsDiphosphonates/administration & dosage/adverse effects/therapeutic useDrug InteractionsHumansInfusions, IntravenousJaw/pathologyOsteonecrosis/chemically inducedSteroids/therapeutic use
PMID: 16323736
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Research groups Groupe Lombardi Tommaso (médecine dentaire) (313)
Groupe Scolozzi Paolo (chirurgie maxillo-faciale et buccale) (896)
Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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JUNOD, Alain et al. Ostéonécrose des maxillaires et bisphosphonates. In: Revue médicale suisse, 2005, vol. 1, n° 39, p. 2537-40,2542-3. https://archive-ouverte.unige.ch/unige:39529

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Deposited on : 2014-08-19

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