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Limited access to UNIGEOther version: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007890-200503150-00006&LSLINK=80&D=ovft
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Scientific Article
unige:39460 
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Macrophage depletion prolongs discordant but not concordant islet xenograft survival |
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| Published in | Transplantation. 2005, vol. 79, no. 5, p. 543-9 | |
| Abstract | T cells and macrophages play a major role in the rejection of xenografted islets. Depending on the phylogenetic disparity, direct or indirect antigen presentation is predominant. The aim of this study was to analyze in vitro the predominance of direct or indirect presentation by depleting antigen-presenting cells in concordant and discordant xenogeneic combinations. In vivo, we analyzed the effect of macrophage depletion on concordant and discordant islet xenograft survival to assess in which combination this strategy can be used as therapeutic tool. | |
| Keywords | Animals — Gadolinium/pharmacology — Graft Survival — Islets of Langerhans Transplantation — Lymphocyte Culture Test, Mixed — Macrophages/physiology — Male — Mice — Mice, Inbred C57BL — Phagocytosis — Rats — Rats, Sprague-Dawley — T-Lymphocytes/immunology — Transplantation, Heterologous | |
| Identifiers | PMID: 15753843 | |
| Full text |
Article (Published version) (2 MB) - Limited access to UNIGE Other version: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007890-200503150-00006&LSLINK=80&D=ovft |
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| Structures | ||
| Research groups | Transplantation et hépatologie (905) Chirurgie viscérale (104) Cultures cellulaires et transplantations (519) La transplantation d'îlots de Langerhans (623) | |
| Citation (ISO format) | ANDRES, Axel et al. Macrophage depletion prolongs discordant but not concordant islet xenograft survival. In: Transplantation, 2005, vol. 79, n° 5, p. 543-9. https://archive-ouverte.unige.ch/unige:39460 |
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