Scientific article

Macrophage depletion prolongs discordant but not concordant islet xenograft survival

Published inTransplantation, vol. 79, no. 5, p. 543-549
Publication date2005

T cells and macrophages play a major role in the rejection of xenografted islets. Depending on the phylogenetic disparity, direct or indirect antigen presentation is predominant. The aim of this study was to analyze in vitro the predominance of direct or indirect presentation by depleting antigen-presenting cells in concordant and discordant xenogeneic combinations. In vivo, we analyzed the effect of macrophage depletion on concordant and discordant islet xenograft survival to assess in which combination this strategy can be used as therapeutic tool.

  • Animals
  • Gadolinium/pharmacology
  • Graft Survival
  • Islets of Langerhans Transplantation
  • Lymphocyte Culture Test, Mixed
  • Macrophages/physiology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Phagocytosis
  • Rats
  • Rats, Sprague-Dawley
  • T-Lymphocytes/immunology
  • Transplantation, Heterologous
Citation (ISO format)
ANDRES, Axel et al. Macrophage depletion prolongs discordant but not concordant islet xenograft survival. In: Transplantation, 2005, vol. 79, n° 5, p. 543–549. doi: 10.1097/01.tp.0000151764.39095.ca
Main files (1)
Article (Published version)
ISSN of the journal0041-1337

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