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Macrophage depletion prolongs discordant but not concordant islet xenograft survival

Mathe, Zoltan
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Published in Transplantation. 2005, vol. 79, no. 5, p. 543-9
Abstract T cells and macrophages play a major role in the rejection of xenografted islets. Depending on the phylogenetic disparity, direct or indirect antigen presentation is predominant. The aim of this study was to analyze in vitro the predominance of direct or indirect presentation by depleting antigen-presenting cells in concordant and discordant xenogeneic combinations. In vivo, we analyzed the effect of macrophage depletion on concordant and discordant islet xenograft survival to assess in which combination this strategy can be used as therapeutic tool.
Keywords AnimalsGadolinium/pharmacologyGraft SurvivalIslets of Langerhans TransplantationLymphocyte Culture Test, MixedMacrophages/physiologyMaleMiceMice, Inbred C57BLPhagocytosisRatsRats, Sprague-DawleyT-Lymphocytes/immunologyTransplantation, Heterologous
PMID: 15753843
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Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
Cultures cellulaires et transplantations (519)
La transplantation d'îlots de Langerhans (623)
Transplantation et hépatologie (905)
(ISO format)
ANDRES, Axel et al. Macrophage depletion prolongs discordant but not concordant islet xenograft survival. In: Transplantation, 2005, vol. 79, n° 5, p. 543-9. doi: 10.1097/01.tp.0000151764.39095.ca https://archive-ouverte.unige.ch/unige:39460

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Deposited on : 2014-08-15

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