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Title

Macrophage depletion prolongs discordant but not concordant islet xenograft survival
Authors
Andres, Axel
Toso, Christian
Morel, Philippe
Bosco, Domenico
Bucher, Pascal Alain Robert
Oberholzer, José
Mathe, Zoltan
Mai, Gang
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Published in Transplantation. 2005, vol. 79, no. 5, p. 543-9
Abstract T cells and macrophages play a major role in the rejection of xenografted islets. Depending on the phylogenetic disparity, direct or indirect antigen presentation is predominant. The aim of this study was to analyze in vitro the predominance of direct or indirect presentation by depleting antigen-presenting cells in concordant and discordant xenogeneic combinations. In vivo, we analyzed the effect of macrophage depletion on concordant and discordant islet xenograft survival to assess in which combination this strategy can be used as therapeutic tool.
Keywords Animals — Gadolinium/pharmacology — Graft Survival — Islets of Langerhans Transplantation — Lymphocyte Culture Test, Mixed — Macrophages/physiology — Male — Mice — Mice, Inbred C57BL — Phagocytosis — Rats — Rats, Sprague-Dawley — T-Lymphocytes/immunology — Transplantation, Heterologous
Identifiers
PMID: 15753843
Full text
Article (Published version) (2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007890-200503150-00006&LSLINK=80&D=ovft
Structures
Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
Cultures cellulaires et transplantations (519)
La transplantation d'îlots de Langerhans (623)
Transplantation et hépatologie (905)
Citation
(ISO format) 		ANDRES, Axel et al. Macrophage depletion prolongs discordant but not concordant islet xenograft survival. In: Transplantation, 2005, vol. 79, n° 5, p. 543-9. doi: 10.1097/01.tp.0000151764.39095.ca https://archive-ouverte.unige.ch/unige:39460

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Deposited on : 2014-08-15

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