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Title

Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance

Authors
Potin, Lambert
Capotosti, Francesca
Suter, Tobias
LeibundGut-Landmann, Salomé
Garbi, Natalio
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Published in Journal of Experimental Medicine. 2014, vol. 211, no. 6, p. 1153-66
Abstract Dendritic cells (DCs), and more recently lymph node stromal cells (LNSCs), have been described to tolerize self-reactive CD8(+) T cells in LNs. Although LNSCs express MHCII, it is unknown whether they can also impact CD4(+) T cell functions. We show that the promoter IV (pIV) of class II transactivator (CIITA), the master regulator of MHCII expression, controls endogenous MHCII expression by LNSCs. Unexpectedly, LNSCs also acquire peptide-MHCII complexes from DCs and induce CD4(+) T cell dysfunction by presenting transferred complexes to naive CD4(+) T cells and preventing their proliferation and survival. Our data reveals a novel, alternative mechanism where LN-resident stromal cells tolerize CD4(+) T cells through the presentation of self-antigens via transferred peptide-MHCII complexes of DC origin.
Identifiers
PMID: 24842370
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Article (Published version) (3.7 MB) - public document Free access
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Research groups Pathologie et immunologie (906)
Groupe Reith Walter (pathologie et immunologie) (282)
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DUBROT ARMENDARIZ, Juan et al. Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance. In: Journal of Experimental Medicine, 2014, vol. 211, n° 6, p. 1153-66. https://archive-ouverte.unige.ch/unige:39295

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Deposited on : 2014-08-08

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