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Scientific article
English

CD74: a new prognostic factor for patients with malignant pleural mesothelioma

ContributorsOtterstrom, Claire; Soltermann, Alex; Opitz, I; Felley-Bosco, E; Weder, W; Stahel, R A; Triponez, Frédéric; Robert, John; Serre Beinier, Véroniqueorcid
Published inBritish journal of cancer, vol. 110, no. 8, p. 2040-2046
Publication date2014
Abstract

The pro-inflammatory cytokine migration inhibitory factor (MIF) and its receptor CD74 have been proposed as possible therapeutic targets in several cancers. We studied the expression of MIF and CD74 together with calretinin in specimens of malignant pleural mesothelioma (MPM), correlating their expression levels with clinico-pathologic parameters, in particular overall survival (OS).

Keywords
  • Aged
  • Antigens, Differentiation, B-Lymphocyte/biosynthesis/genetics
  • Calbindin 2/biosynthesis
  • Female
  • Gene Expression Regulation, Neoplastic
  • Histocompatibility Antigens Class II/biosynthesis/genetics
  • Humans
  • Intramolecular Oxidoreductases/biosynthesis
  • Lung Neoplasms/genetics/pathology
  • Macrophage Migration-Inhibitory Factors/biosynthesis
  • Male
  • Mesothelioma/genetics/pathology
  • Middle Aged
  • PTEN Phosphohydrolase/biosynthesis
  • Prognosis
  • Tissue Array Analysis
  • Tumor Markers, Biological/biosynthesis/genetics
Affiliation entities
Research groups
Citation (ISO format)
OTTERSTROM, Claire et al. CD74: a new prognostic factor for patients with malignant pleural mesothelioma. In: British journal of cancer, 2014, vol. 110, n° 8, p. 2040–2046. doi: 10.1038/bjc.2014.117
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0007-0920
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Technical informations

Creation04/08/2014 17:42:00
First validation04/08/2014 17:42:00
Update time14/03/2023 22:30:27
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