Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation

Andres, Axel; Toso, Christian; Morel, Philippe; Bosco, Domenico; Bucher, Pascal Alain Robert; Oberholzer, José; Mathe, Z; Mai, Gang; Wekerle, T; Berney, Thierry; Buehler, Leo Hans

doi:10.1016/j.transproceed.2004.11.074

Scientific article

English

Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation

ContributorsAndres, Axel; Toso, Christian; Morel, Philippe; Bosco, Domenico; Bucher, Pascal Alain Robert; Oberholzer, José; Mathe, Z; Mai, Gang; Wekerle, T; Berney, Thierry; Buehler, Leo Hans

Published inTransplantation proceedings, vol. 37, no. 1, p. 463-465

Publication date2005

Abstract

Cellular immunity plays a major role in rejection of xenografted islets. Depending on the phylogenetical disparity, direct or indirect antigen presentation is predominant. The aim of this study was to analyze in vitro the predominance of direct or indirect presentation, and in vivo the effect of macrophage depletion on concordant and discordant islet xenograft survival.

Keywords

Animals
Antigen Presentation/immunology
Graft Rejection/immunology
Graft Survival/immunology
Humans
Islets of Langerhans Transplantation/immunology
Lymphocyte Culture Test, Mixed
Male
Mice
Mice, Inbred C57BL
Phylogeny
Rats
Rats, Sprague-Dawley
Time Factors
Transplantation, Heterologous/immunology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Citation (ISO format)

ANDRES, Axel et al. Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation. In: Transplantation proceedings, 2005, vol. 37, n° 1, p. 463–465. doi: 10.1016/j.transproceed.2004.11.074

Article (Published version)

Identifiers

PID : unige:39208
DOI : 10.1016/j.transproceed.2004.11.074
PMID : 15808677

ISSN of the journal0041-1345

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Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation

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