en
Scientific article
English

Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation

Published inTransplantation proceedings, vol. 37, no. 1, p. 463-465
Publication date2005
Abstract

Cellular immunity plays a major role in rejection of xenografted islets. Depending on the phylogenetical disparity, direct or indirect antigen presentation is predominant. The aim of this study was to analyze in vitro the predominance of direct or indirect presentation, and in vivo the effect of macrophage depletion on concordant and discordant islet xenograft survival.

Keywords
  • Animals
  • Antigen Presentation/immunology
  • Graft Rejection/immunology
  • Graft Survival/immunology
  • Humans
  • Islets of Langerhans Transplantation/immunology
  • Lymphocyte Culture Test, Mixed
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Phylogeny
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors
  • Transplantation, Heterologous/immunology
Citation (ISO format)
ANDRES, Axel et al. Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation. In: Transplantation proceedings, 2005, vol. 37, n° 1, p. 463–465. doi: 10.1016/j.transproceed.2004.11.074
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0041-1345
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