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Scientific article
English

Emotions are building up in the field of extracellular proteolysis

Published inTrends in molecular medicine, vol. 9, no. 5, p. 183-185
Publication date2003
Abstract

Activity-dependent remodeling of neural connections might require localized extracellular proteolysis. The tissue-type plasminogen activator (tPA)-plasmin proteolytic system is expressed in different regions of the central nervous system, in the context of a variety of physiological and pathological processes. Accumulating evidence regarding the expression and role of tPA and its inhibitors suggests that extracellular proteolysis is a key player in the biology of memory, emotions and neurodegeneration.

Keywords
  • Animals
  • Emotions/physiology
  • Mice
  • Nervous System/metabolism
  • Neuropeptides/metabolism
  • Serpins/metabolism
  • Tissue Plasminogen Activator/metabolism
Citation (ISO format)
MADANI, Rime, NEF, Serge, VASSALLI, Jean-Dominique. Emotions are building up in the field of extracellular proteolysis. In: Trends in molecular medicine, 2003, vol. 9, n° 5, p. 183–185. doi: 10.1016/S1471-4914(03)00050-9
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Article (Accepted version)
accessLevelRestricted
Identifiers
ISSN of the journal1471-4914
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Creation10/23/2009 3:04:00 PM
First validation10/23/2009 3:04:00 PM
Update time03/14/2023 3:16:52 PM
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