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Emotions are building up in the field of extracellular proteolysis

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Published in Trends in Molecular Medicine. 2003, vol. 9, no. 5, p. 183-5
Abstract Activity-dependent remodeling of neural connections might require localized extracellular proteolysis. The tissue-type plasminogen activator (tPA)-plasmin proteolytic system is expressed in different regions of the central nervous system, in the context of a variety of physiological and pathological processes. Accumulating evidence regarding the expression and role of tPA and its inhibitors suggests that extracellular proteolysis is a key player in the biology of memory, emotions and neurodegeneration.
Keywords AnimalsEmotions/physiologyMiceNervous System/metabolismNeuropeptides/metabolismSerpins/metabolismTissue Plasminogen Activator/metabolism
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PMID: 12763521
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MADANI, Rime, NEF, Serge, VASSALLI, Jean-Dominique. Emotions are building up in the field of extracellular proteolysis. In: Trends in Molecular Medicine, 2003, vol. 9, n° 5, p. 183-5. https://archive-ouverte.unige.ch/unige:3901

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Deposited on : 2009-10-23

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