Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells

Gerber, Philipp A; Bellomo, Elisa A; Hodson, David J; Meur, Gargi; Solomou, Antonia; Mitchell, Ryan K; Hollinshead, Michael; Chimienti, Fabrice; Bosco, Domenico; Hughes, Stephen J; Johnson, Paul R V; Rutter, Guy A

doi:10.1007/s00125-014-3266-0

Scientific article

English

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells

ContributorsGerber, Philipp A; Bellomo, Elisa A; Hodson, David J; Meur, Gargi; Solomou, Antonia; Mitchell, Ryan K; Hollinshead, Michael; Chimienti, Fabrice; Bosco, Domenico; Hughes, Stephen J; Johnson, Paul R V; Rutter, Guy A

Published inDiabetologia, vol. 57, no. 8, p. 1635-1644

Publication date2014

Abstract

Hypoxic damage complicates islet isolation for transplantation and may contribute to beta cell failure in type 2 diabetes. Polymorphisms in the SLC30A8 gene, encoding the secretory granule zinc transporter 8 (ZnT8), influence type 2 diabetes risk, conceivably by modulating cytosolic Zn(2+) levels. We have therefore explored the role of ZnT8 and cytosolic Zn(2+) in the response to hypoxia of pancreatic islet cells.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Cultures cellulaires et transplantations (519)

Citation (ISO format)

GERBER, Philipp A et al. Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells. In: Diabetologia, 2014, vol. 57, n° 8, p. 1635–1644. doi: 10.1007/s00125-014-3266-0

Article (Published version)

Identifiers

PID : unige:38917
DOI : 10.1007/s00125-014-3266-0
PMID : 24865615

Journal ISSN0012-186X

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Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells

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