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Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells

Published inDiabetologia, vol. 57, no. 8, p. 1635-1644
Publication date2014
Abstract

Hypoxic damage complicates islet isolation for transplantation and may contribute to beta cell failure in type 2 diabetes. Polymorphisms in the SLC30A8 gene, encoding the secretory granule zinc transporter 8 (ZnT8), influence type 2 diabetes risk, conceivably by modulating cytosolic Zn(2+) levels. We have therefore explored the role of ZnT8 and cytosolic Zn(2+) in the response to hypoxia of pancreatic islet cells.

Citation (ISO format)
GERBER, Philipp A et al. Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn(2+) in pancreatic beta cells. In: Diabetologia, 2014, vol. 57, n° 8, p. 1635–1644. doi: 10.1007/s00125-014-3266-0
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ISSN of the journal0012-186X
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Creation07/24/2014 2:54:00 PM
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