UNIGE document Scientific Article
previous document  unige:38280  next document
add to browser collection
Title

Annotation of post-translational modifications in the Swiss-Prot knowledge base

Authors
Garavelli, John S
Published in Proteomics. 2004, vol. 4, no. 6, p. 1537-50
Abstract High-throughput proteomic studies produce a wealth of new information regarding post-translational modifications (PTMs). The Swiss-Prot knowledge base is faced with the challenge of including this information in a consistent and structured way, in order to facilitate easy retrieval and promote understanding by biologist expert users as well as computer programs. We are therefore standardizing the annotation of PTM features represented in Swiss-Prot. Indeed, a controlled vocabulary has been associated with every described PTM. In this paper, we present the major update of the feature annotation, and, by showing a few examples, explain how the annotation is implemented and what it means. Mod-Prot, a future companion database of Swiss-Prot, devoted to the biological aspects of PTMs (i.e., general description of the process, identity of the modification enzyme(s), taxonomic range, mass modification) is briefly described. Finally we encourage once again the scientific community (i.e., both individual researchers and database maintainers) to interact with us, so that we can continuously enhance the quality and swiftness of our services.
Keywords Computational BiologyDatabases, Protein/standardsForecastingInformation SystemsProtein Processing, Post-TranslationalSequence Analysis, ProteinSystems Integration
Identifiers
PMID: 15174124
Full text
Structures
Research groups Calipho (80)
Swiss-Prot Research Group
Swiss Institute of Bioinformatics
Citation
(ISO format)
FARRIOL-MATHIS, Nathalie et al. Annotation of post-translational modifications in the Swiss-Prot knowledge base. In: Proteomics, 2004, vol. 4, n° 6, p. 1537-50. https://archive-ouverte.unige.ch/unige:38280

182 hits

0 download

Update

Deposited on : 2014-06-27

Export document
Format :
Citation style :