Aspirin is commonly used most often at low daily doses. We report a case of acute aspirin intoxication resulting in a transitory hearing loss, tinnitus, and vertigo. Such intoxications occur at doses of several grams. The disorders caused by aspirin are fortunately reversible. The mechanisms of ototoxicity appear to involve, in part, electro-mobility of the outer hair cells of the inner ear by inhibiting the movement of prestin.