Scientific article
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English

Induction of influenza-specific mucosal immunity by an attenuated recombinant Sendai virus

Published inPloS one, vol. 6, no. 4, e18780
Publication date2011
Abstract

Many pathogens initiate infection at the mucosal surfaces; therefore, induction of mucosal immune responses is a first level of defense against infection and is the most powerful means of protection. Although intramuscular injection is widely used for vaccination and is effective at inducing circulating antibodies, it is less effective at inducing mucosal antibodies.

Keywords
  • Animals
  • Antibodies, Viral/biosynthesis
  • Genetic Vectors
  • Genome, Viral
  • Immunity, Mucosal
  • Influenza A virus/immunology/isolation & purification
  • Mice
  • Orthomyxoviridae Infections/immunology/prevention & control/virology
  • Recombination, Genetic
  • Sendai virus/genetics/physiology
Citation (ISO format)
LE, Thuc-vy L et al. Induction of influenza-specific mucosal immunity by an attenuated recombinant Sendai virus. In: PloS one, 2011, vol. 6, n° 4, p. e18780. doi: 10.1371/journal.pone.0018780
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Article (Published version)
Identifiers
ISSN of the journal1932-6203
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323downloads

Technical informations

Creation06/16/2014 11:11:00 AM
First validation06/16/2014 11:11:00 AM
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