Article (Published version) (326 Kb) - Free access
Sweet taste loss in myasthenia gravis: more than a coincidence?
|Published in||Orphanet Journal of Rare Diseases. 2014, vol. 9, no. 1, p. 50|
|Abstract||Sweet dysgeusia, a rare taste disorder, may be encountered in severe anti-acetylcholine receptor antibody (AChRAb)-myasthenia gravis (MG). A 42 year-old man reported progressive loss of sweet taste evolving for almost 10 weeks, revealing an AChRAb-positive MG with thymoma. Improvement of sweet perception paralleled reduction of the MG composite score during the 15 months follow up period, with immunosuppressive and surgical treatments. We suggest that sweet dysgeusia is a non-motor manifestation of MG that may result from a thymoma-dependent autoimmune mechanism targeting gustducin-positive G-protein-coupled taste receptor cells, in line with recent data from MRL/MpJ-Fas lpr/ (MRL/lpr) transgenic mice with autoimmune disease.|
|CHABWINE, Joelle N et al. Sweet taste loss in myasthenia gravis: more than a coincidence?. In: Orphanet Journal of Rare Diseases, 2014, vol. 9, n° 1, p. 50. https://archive-ouverte.unige.ch/unige:37966|