Impact of a sirolimus/tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation

Andres, Axel; Toso, Christian; Morel, Philippe; Demuylder-Mischler, S; Bosco, Domenico; Baertschiger, Reto Marc; Pernin, Nadine; Bucher, Pascal Alain Robert; Majno, Pietro; Buehler, Leo Hans; Berney, Thierry

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Title		Impact of a sirolimus/tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation
Authors		Andres, Axel Toso, Christian Morel, Philippe Demuylder-Mischler, S Bosco, Domenico Baertschiger, Reto Marc Pernin, Nadine Bucher, Pascal Alain Robert Majno, Pietro Buehler, Leo Hans Berney, Thierry show all authors [1 - 11]
Published in		Transplantation Proceedings. 2005, vol. 37, no. 2, p. 1326-7
Abstract		Islet transplantation is gaining recognition as a therapeutic option for selected diabetic patients. The immunosuppressive regimen based on sirolimus/low-dose tacrolimus is considered a major breakthrough that allowed considerable improvement in graft survival. A high incidence of side effects associated with such a regimen has been reported in the literature, but this immunosuppressive protocol is generally considered safe or even protective to the kidney. Herein, we analyze the impact of the sirolimus/low-dose tacrolimus-based protocol on kidney function.
Keywords		Creatinine/metabolism — Diabetes Mellitus, Type 1/drug therapy/surgery — Drug Therapy, Combination — Follow-Up Studies — Humans — Hypoglycemic Agents/therapeutic use — Immunosuppressive Agents/therapeutic use — Insulin/therapeutic use — Islets of Langerhans Transplantation/immunology/methods/physiology — Kidney Function Tests — Sirolimus/therapeutic use — Tacrolimus/therapeutic use — Treatment Outcome
Identifiers		DOI: 10.1016/j.transproceed.2004.12.040 PMID: 15848711
Full text		Article (Published version) (79 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups		Chirurgie viscérale (104) Hépatologie chirurgicale (327) La transplantation d'îlots de Langerhans (623) Cultures cellulaires et transplantations (519)
Citation (ISO format)		ANDRES, Axel et al. Impact of a sirolimus/tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation. In: Transplantation Proceedings, 2005, vol. 37, n° 2, p. 1326-7. https://archive-ouverte.unige.ch/unige:37082