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Impact of a sirolimus/tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation

Demuylder-Mischler, S
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Published in Transplantation proceedings. 2005, vol. 37, no. 2, p. 1326-7
Abstract Islet transplantation is gaining recognition as a therapeutic option for selected diabetic patients. The immunosuppressive regimen based on sirolimus/low-dose tacrolimus is considered a major breakthrough that allowed considerable improvement in graft survival. A high incidence of side effects associated with such a regimen has been reported in the literature, but this immunosuppressive protocol is generally considered safe or even protective to the kidney. Herein, we analyze the impact of the sirolimus/low-dose tacrolimus-based protocol on kidney function.
Keywords Creatinine/metabolismDiabetes Mellitus, Type 1/drug therapy/surgeryDrug Therapy, CombinationFollow-Up StudiesHumansHypoglycemic Agents/therapeutic useImmunosuppressive Agents/therapeutic useInsulin/therapeutic useIslets of Langerhans Transplantation/immunology/methods/physiologyKidney Function TestsSirolimus/therapeutic useTacrolimus/therapeutic useTreatment Outcome
PMID: 15848711
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Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
Cultures cellulaires et transplantations (519)
Hépatologie chirurgicale (327)
La transplantation d'îlots de Langerhans (623)
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ANDRES, Axel et al. Impact of a sirolimus/tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation. In: Transplantation proceedings, 2005, vol. 37, n° 2, p. 1326-7. doi: 10.1016/j.transproceed.2004.12.040 https://archive-ouverte.unige.ch/unige:37082

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Deposited on : 2014-06-03

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