Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1
Contributeurs/tricesMaedler, Kathrin; Schumann, Desiree; Schulthess, Fabienne; Oberholzer, José; Bosco, Domenico; Berney, Thierry; Donath, Marc Y
Publié dansDiabetes, vol. 55, no. 9, p. 2455-2462
Date de publication2006
Résumé
Mots-clés
- Adolescent
- Adult
- Aged
- Aging/physiology
- Animals
- Antigens, CD95/physiology
- Apoptosis/drug effects/physiology
- Cell Proliferation
- Cells, Cultured
- Fas Ligand Protein
- Glucose/pharmacology
- Homeodomain Proteins/physiology
- Humans
- Insulin-Secreting Cells/cytology
- Male
- Membrane Glycoproteins/physiology
- Middle Aged
- Rats
- Rats, Sprague-Dawley
- Trans-Activators/physiology
- Tumor Necrosis Factors/physiology
Structure d'affiliation
Groupe de recherche
Citation (format ISO)
MAEDLER, Kathrin et al. Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1. In: Diabetes, 2006, vol. 55, n° 9, p. 2455–2462. doi: 10.2337/db05-1586
Fichiers principaux (1)
Article (Published version)
Identifiants
- PID : unige:36975
- DOI : 10.2337/db05-1586
- PMID : 16936193
ISSN du journal0012-1797