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Protein variety and functional diversity: Swiss-Prot annotation in its biological context

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Published in Comptes rendus biologies. 2005, vol. 328, no. 10-11, p. 882-99
Abstract We all know that the dogma 'one gene, one protein' is obsolete. A functional protein and, likewise, a protein's ultimate function depend not only on the underlying genetic information but also on the ongoing conditions of the cellular system. Frequently the transcript, like the polypeptide, is processed in multiple ways, but only one or a few out of a multitude of possible variants are produced at a time. An overview on processes that can lead to sequence variety and structural diversity in eukaryotes is given. The UniProtKB/Swiss-Prot protein knowledgebase provides a wealth of information regarding protein variety, function and associated disorders. Examples for such annotation are shown and further ones are available at http://www.expasy.org/sprot/tutorial/examples_CRB.
Keywords Amino Acid SequenceKnowledge BasesMolecular Sequence DataProtein FoldingProteins/chemistry
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PMID: 16286078
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Structures
Research groups Calipho (80)
Swiss-Prot Research Group
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BOECKMANN, Brigitte et al. Protein variety and functional diversity: Swiss-Prot annotation in its biological context. In: Comptes rendus biologies, 2005, vol. 328, n° 10-11, p. 882-99. https://archive-ouverte.unige.ch/unige:36663

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Deposited on : 2014-05-16

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