The Universal Protein Resource (UniProt): an expanding universe of protein information

Wu, Cathy H; Apweiler, Rolf; Bairoch, Amos Marc; Natale, Darren A; Barker, Winona C; Boeckmann, Brigitte; Ferro Rojas, Serenella; Gasteiger, Elisabeth; Huang, Hongzhan; Lopez, Rodrigo; Magrane, Michele; Martin, Maria J; Mazumder, Raja; O'Donovan, Claire; Redaschi, Nicole; Suzek, Baris

doi:10.1093/nar/gkj161

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Title		The Universal Protein Resource (UniProt): an expanding universe of protein information
Authors		Wu, Cathy H Apweiler, Rolf Bairoch, Amos Marc Natale, Darren A Barker, Winona C Boeckmann, Brigitte Ferro Rojas, Serenella Gasteiger, Elisabeth Huang, Hongzhan Lopez, Rodrigo Magrane, Michele Martin, Maria J Mazumder, Raja O'Donovan, Claire Redaschi, Nicole Suzek, Baris show all authors [1 - 16]
Published in		Nucleic Acids Research. 2006, vol. 34, no. Database issue, p. D187-91
Abstract		The Universal Protein Resource (UniProt) provides a central resource on protein sequences and functional annotation with three database components, each addressing a key need in protein bioinformatics. The UniProt Knowledgebase (UniProtKB), comprising the manually annotated UniProtKB/Swiss-Prot section and the automatically annotated UniProtKB/TrEMBL section, is the preeminent storehouse of protein annotation. The extensive cross-references, functional and feature annotations and literature-based evidence attribution enable scientists to analyse proteins and query across databases. The UniProt Reference Clusters (UniRef) speed similarity searches via sequence space compression by merging sequences that are 100% (UniRef100), 90% (UniRef90) or 50% (UniRef50) identical. Finally, the UniProt Archive (UniParc) stores all publicly available protein sequences, containing the history of sequence data with links to the source databases. UniProt databases continue to grow in size and in availability of information. Recent and upcoming changes to database contents, formats, controlled vocabularies and services are described. New download availability includes all major releases of UniProtKB, sequence collections by taxonomic division and complete proteomes. A bibliography mapping service has been added, and an ID mapping service will be available soon. UniProt databases can be accessed online at http://www.uniprot.org or downloaded at ftp://ftp.uniprot.org/pub/databases/.
Keywords		Databases — Protein — Internet — Proteins/chemistry/classification/physiology — Proteome/chemistry — Sequence Analysis — Systems Integration — User-Computer Interface
Identifiers		DOI: 10.1093/nar/gkj161 PMID: 16381842
Full text		Article (Published version) (253 Kb) - Free access Other version: http://www.uniprot.org/
Structures		Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research group		Calipho (80)
Citation (ISO format)		WU, Cathy H et al. The Universal Protein Resource (UniProt): an expanding universe of protein information. In: Nucleic Acids Research, 2006, vol. 34, n° Database issue, p. D187-91. doi: 10.1093/nar/gkj161 https://archive-ouverte.unige.ch/unige:36469