Mass spectrometry in high-throughput proteomics: ready for the big time

Nilsson, Tommy; Mann, Matthias; Aebersold, Ruedi; Yates, John R (3rd); Bairoch, Amos Marc; Bergeron, John J M

doi:10.1038/nmeth0910-681

Scientific article

English

Mass spectrometry in high-throughput proteomics: ready for the big time

ContributorsNilsson, Tommy; Mann, Matthias; Aebersold, Ruedi; Yates, John R (3rd); Bairoch, Amos Marc

; Bergeron, John J M

Published inNature methods, vol. 7, no. 9, p. 681-685

Publication date2010

Abstract

Mass spectrometry has evolved and matured to a level where it is able to assess the complexity of the human proteome. We discuss some of the expected challenges ahead and promising strategies for success.

Keywords

Databases, Protein
Humans
Mass Spectrometry/trends
Proteome/analysis
Proteomics/methods
Quality Control
Reproducibility of Results
Sensitivity and Specificity

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique

Research groups

Calipho (80)

Citation (ISO format)

NILSSON, Tommy et al. Mass spectrometry in high-throughput proteomics: ready for the big time. In: Nature methods, 2010, vol. 7, n° 9, p. 681–685. doi: 10.1038/nmeth0910-681

Article (Published version)

Identifiers

PID : unige:36263
DOI : 10.1038/nmeth0910-681
PMID : 20805795

Journal ISSN1548-7091

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Mass spectrometry in high-throughput proteomics: ready for the big time

Mass spectrometry has evolved and matured to a level where it is able to assess the complexity of the human proteome. We discuss some of the expected challenges ahead and promising strategies for success.

Technical informations