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A unique signature identifies a family of zinc-dependent metallopeptidases

Jongeneel, C Victor
Bouvier, Jacques
Published in FEBS Letters. 1989, vol. 242, no. 2, p. 211-4
Abstract The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.
Keywords Amino Acid SequenceAnimalsHumansMetalloendopeptidasesStructure-Activity Relationship
PMID: 2914602
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Research group Calipho (80)
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JONGENEEL, C Victor, BOUVIER, Jacques, BAIROCH, Amos Marc. A unique signature identifies a family of zinc-dependent metallopeptidases. In: FEBS Letters, 1989, vol. 242, n° 2, p. 211-4. doi: 10.1016/0014-5793(89)80471-5 https://archive-ouverte.unige.ch/unige:36238

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Deposited on : 2014-05-02

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