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Domino Asymmetric Conjugate Addition–Conjugate Addition

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Published in Organic Letters. 2014, vol. 16, no. 7, p. 2006-2009
Abstract Enantioenriched Al-, Mg-, and Zn-enolates undergo electrophilic trapping by nitroolefins and vinylsulfones to afford 1,4-diketones and 2-(bis(phenylsulfonyl)ethyl)ketones in good yield and excellent diastereoselectivity. A one-pot preparation of indenes and enantiopure syntheses of tetrahydrobenzofurans, tetrahydrobenzopyrroles, and azulenes are disclosed. A site-selective two-step sequence of three conjugate additions is also demonstrated.
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Other version: http://pubs.acs.org/doi/abs/10.1021/ol5005752
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GERMAIN, Nicolas et al. Domino Asymmetric Conjugate Addition–Conjugate Addition. In: Organic Letters, 2014, vol. 16, n° 7, p. 2006-2009. https://archive-ouverte.unige.ch/unige:35768

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Deposited on : 2014-04-16

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