en
Scientific article
English

Domino Asymmetric Conjugate Addition–Conjugate Addition

Published inOrganic letters, vol. 16, no. 7, p. 2006-2009
Publication date2014
Abstract

Enantioenriched Al-, Mg-, and Zn-enolates undergo electrophilic trapping by nitroolefins and vinylsulfones to afford 1,4-diketones and 2-(bis(phenylsulfonyl)ethyl)ketones in good yield and excellent diastereoselectivity. A one-pot preparation of indenes and enantiopure syntheses of tetrahydrobenzofurans, tetrahydrobenzopyrroles, and azulenes are disclosed. A site-selective two-step sequence of three conjugate additions is also demonstrated.

Citation (ISO format)
GERMAIN, Nicolas et al. Domino Asymmetric Conjugate Addition–Conjugate Addition. In: Organic letters, 2014, vol. 16, n° 7, p. 2006–2009. doi: 10.1021/ol5005752
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ISSN of the journal1523-7052
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