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Scientific article
English

Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model

Published inJournal of thoracic and cardiovascular surgery, vol. 133, no. 5, p. 1163-1170
Publication date2007
Abstract

Intimal hyperplasia and surface thrombogenicity are major factors in the high failure rate of synthetic small-diameter bypass grafts. Vascular endothelial growth factor is a potent stimulus for endothelial growth, and its provision in a fibrin matrix coating at the luminal graft surface may hold a key to spontaneous graft endothelialization and improved graft patency.

Keywords
  • Animals
  • Blood Vessel Prosthesis
  • Blood Vessel Prosthesis Implantation
  • Capillaries/pathology
  • Carotid Arteries/pathology/surgery
  • Coated Materials, Biocompatible
  • Fibrin/pharmacology
  • Graft Occlusion, Vascular/pathology
  • Immunohistochemistry
  • Macrophages/pathology
  • Polytetrafluoroethylene
  • Sus scrofa
  • Tunica Intima/pathology
  • Vascular Endothelial Growth Factor A/pharmacology
  • Vascular Patency
Citation (ISO format)
WALPOTH, Beat et al. Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model. In: Journal of thoracic and cardiovascular surgery, 2007, vol. 133, n° 5, p. 1163–1170. doi: 10.1016/j.jtcvs.2007.01.029
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Article (Published version)
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Identifiers
ISSN of the journal0022-5223
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