Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model

Walpoth, Beat; Zammaretti Schaer, Prisca; Cikirikcioglu, Mustafa; Khabiri, Ebrahim; Djebaili, Merzouk Karim; Pache, Jean-Claude; Tille, Jean-Christophe; Aggoun, Yacine; Morel, Denis; Kalangos, Afksendiyos; Hubbell, Jeffrey A; Zisch, Andreas H

doi:10.1016/j.jtcvs.2007.01.029

Scientific article

English

Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model

ContributorsWalpoth, Beat; Zammaretti Schaer, Prisca; Cikirikcioglu, Mustafa; Khabiri, Ebrahim; Djebaili, Merzouk Karim; Pache, Jean-Claude; Tille, Jean-Christophe; Aggoun, Yacine; Morel, Denis; Kalangos, Afksendiyos; Hubbell, Jeffrey A; Zisch, Andreas H

Published inJournal of thoracic and cardiovascular surgery, vol. 133, no. 5, p. 1163-1170

Publication date2007

Abstract

Intimal hyperplasia and surface thrombogenicity are major factors in the high failure rate of synthetic small-diameter bypass grafts. Vascular endothelial growth factor is a potent stimulus for endothelial growth, and its provision in a fibrin matrix coating at the luminal graft surface may hold a key to spontaneous graft endothelialization and improved graft patency.

Keywords

Animals
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation
Capillaries/pathology
Carotid Arteries/pathology/surgery
Coated Materials, Biocompatible
Fibrin/pharmacology
Graft Occlusion, Vascular/pathology
Immunohistochemistry
Macrophages/pathology
Polytetrafluoroethylene
Sus scrofa
Tunica Intima/pathology
Vascular Endothelial Growth Factor A/pharmacology
Vascular Patency

Affiliation

Research group

Citation (ISO format)

WALPOTH, Beat et al. Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model. In: Journal of thoracic and cardiovascular surgery, 2007, vol. 133, n° 5, p. 1163–1170. doi: 10.1016/j.jtcvs.2007.01.029

Article (Published version)

Identifiers

PID : unige:35292
DOI : 10.1016/j.jtcvs.2007.01.029
PMID : 17467424

ISSN of the journal0022-5223

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Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model

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