

![]() |
Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model |
|
Authors | ![]() | |
Published in | Journal of Thoracic and Cardiovascular Surgery. 2007, vol. 133, no. 5, p. 1163-70 | |
Abstract | Intimal hyperplasia and surface thrombogenicity are major factors in the high failure rate of synthetic small-diameter bypass grafts. Vascular endothelial growth factor is a potent stimulus for endothelial growth, and its provision in a fibrin matrix coating at the luminal graft surface may hold a key to spontaneous graft endothelialization and improved graft patency. | |
Keywords | Animals — Blood Vessel Prosthesis — Blood Vessel Prosthesis Implantation — Capillaries/pathology — Carotid Arteries/pathology/surgery — Coated Materials, Biocompatible — Fibrin/pharmacology — Graft Occlusion, Vascular/pathology — Immunohistochemistry — Macrophages/pathology — Polytetrafluoroethylene — Sus scrofa — Tunica Intima/pathology — Vascular Endothelial Growth Factor A/pharmacology — Vascular Patency | |
Identifiers | PMID: 17467424 | |
Full text | ||
Structures | ||
Research groups | Chirurgie cardio-vasculaire (105) Groupe Pache Jean-Claude (pathologie clinique) (658) | |
Citation (ISO format) | WALPOTH, Beat et al. Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model. In: Journal of Thoracic and Cardiovascular Surgery, 2007, vol. 133, n° 5, p. 1163-70. doi: 10.1016/j.jtcvs.2007.01.029 https://archive-ouverte.unige.ch/unige:35292 |