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Title

Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model

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Published in Journal of Thoracic and Cardiovascular Surgery. 2007, vol. 133, no. 5, p. 1163-70
Abstract Intimal hyperplasia and surface thrombogenicity are major factors in the high failure rate of synthetic small-diameter bypass grafts. Vascular endothelial growth factor is a potent stimulus for endothelial growth, and its provision in a fibrin matrix coating at the luminal graft surface may hold a key to spontaneous graft endothelialization and improved graft patency.
Keywords AnimalsBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCapillaries/pathologyCarotid Arteries/pathology/surgeryCoated Materials, BiocompatibleFibrin/pharmacologyGraft Occlusion, Vascular/pathologyImmunohistochemistryMacrophages/pathologyPolytetrafluoroethyleneSus scrofaTunica Intima/pathologyVascular Endothelial Growth Factor A/pharmacologyVascular Patency
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PMID: 17467424
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Article (Published version) (1.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Chirurgie cardio-vasculaire (105)
Groupe Pache Jean-Claude (pathologie clinique) (658)
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WALPOTH, Beat et al. Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model. In: Journal of Thoracic and Cardiovascular Surgery, 2007, vol. 133, n° 5, p. 1163-70. https://archive-ouverte.unige.ch/unige:35292

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Deposited on : 2014-04-02

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