Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model

Walpoth, Beat; Zammaretti Schaer, Prisca; Cikirikcioglu, Mustafa; Khabiri, Ebrahim; Djebaili, Merzouk Karim; Pache, Jean-Claude; Tille, Jean-Christophe; Aggoun, Yacine; Morel, Denis; Kalangos, Afksendiyos; Hubbell, Jeffrey A; Zisch, Andreas H

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Title		Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model
Authors		Walpoth, Beat Zammaretti Schaer, Prisca Cikirikcioglu, Mustafa Khabiri, Ebrahim Djebaili, Merzouk Karim Pache, Jean-Claude Tille, Jean-Christophe Aggoun, Yacine Morel, Denis Kalangos, Afksendiyos Hubbell, Jeffrey A Zisch, Andreas H show all authors [1 - 12]
Published in		Journal of Thoracic and Cardiovascular Surgery. 2007, vol. 133, no. 5, p. 1163-70
Abstract		Intimal hyperplasia and surface thrombogenicity are major factors in the high failure rate of synthetic small-diameter bypass grafts. Vascular endothelial growth factor is a potent stimulus for endothelial growth, and its provision in a fibrin matrix coating at the luminal graft surface may hold a key to spontaneous graft endothelialization and improved graft patency.
Keywords		Animals — Blood Vessel Prosthesis — Blood Vessel Prosthesis Implantation — Capillaries/pathology — Carotid Arteries/pathology/surgery — Coated Materials, Biocompatible — Fibrin/pharmacology — Graft Occlusion, Vascular/pathology — Immunohistochemistry — Macrophages/pathology — Polytetrafluoroethylene — Sus scrofa — Tunica Intima/pathology — Vascular Endothelial Growth Factor A/pharmacology — Vascular Patency
Identifiers		DOI: 10.1016/j.jtcvs.2007.01.029 PMID: 17467424
Full text		Article (Published version) (1.4 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de pédiatrie
Research groups		Chirurgie cardio-vasculaire (105) Groupe Pache Jean-Claude (pathologie clinique) (658)
Citation (ISO format)		WALPOTH, Beat et al. Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model. In: Journal of Thoracic and Cardiovascular Surgery, 2007, vol. 133, n° 5, p. 1163-70. https://archive-ouverte.unige.ch/unige:35292