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Implantation de chondrocytes autologues pour les lésions cartilagineuses focales : le point en 2007

Published in Revue médicale suisse. 2007, vol. 3, no. 120, p. 1770,1772-5
Abstract Autologous chondrocyte implantation (ACI) is a frequently used procedure for full-thickness cartilage lesions in the knee joint. However, to date, there are just a few prospective, randomized clinical studies and most publications are case series on small and heterogenic cohorts with short-term follow-up. To date, ACI is a surgical treatment option for single traumatic lesions on the distal femur in young active subjects with a recent lesion. Lesion size should be between 3 and 8 cm2, < 6 mm in depth, tidemark preserved without penetration of the subchondral bone. Absolute contraindications for ACI include osteoarthrosis, kissing lesions, lesions size greater than 10 cm2 or deeper than 8 mm, ligament instability, partial or total meniscectomy, axis malalignment > 5. Further studies are mandatory to determine the precise indications to the technique and to show its superiority on the established treatment of chondral lesions.
Keywords Cartilage Diseases/therapyCell Culture Techniques/methodsCell Transplantation/methods/trendsChondrocytes/cytology/transplantationHumansPatient SelectionResearch/trendsTransplantation, Autologous
PMID: 17850004
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Research group Thérapie cellulaire et troubles musculo-squelettiques (960)
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GARAVAGLIA, Guido et al. Implantation de chondrocytes autologues pour les lésions cartilagineuses focales : le point en 2007. In: Revue médicale suisse, 2007, vol. 3, n° 120, p. 1770,1772-5. https://archive-ouverte.unige.ch/unige:34992

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Deposited on : 2014-03-25

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