Implantation de chondrocytes autologues pour les lésions cartilagineuses focales : le point en 2007

Article Article scientifique Article Implantation de chondrocytes autologues pour les lésions cartilagineuses focales : le point en 2007 fre 2007 author Garavaglia Guido 590317 author Lubowicki Anne 636875 author Fritschy Daniel 24486 author Menetrey Jacques 105033 1770,1772-1775 17850004 1660-9379 Autologous chondrocyte implantation (ACI) is a frequently used procedure for full-thickness cartilage lesions in the knee joint. However, to date, there are just a few prospective, randomized clinical studies and most publications are case series on small and heterogenic cohorts with short-term follow-up. To date, ACI is a surgical treatment option for single traumatic lesions on the distal femur in young active subjects with a recent lesion. Lesion size should be between 3 and 8 cm2, < 6 mm in depth, tidemark preserved without penetration of the subchondral bone. Absolute contraindications for ACI include osteoarthrosis, kissing lesions, lesions size greater than 10 cm2 or deeper than 8 mm, ligament instability, partial or total meniscectomy, axis malalignment > 5. Further studies are mandatory to determine the precise indications to the technique and to show its superiority on the established treatment of chondral lesions. Cartilage Diseases/therapy Cell Culture Techniques/methods Cell Transplantation/methods/trends Chondrocytes/cytology/transplantation Humans Patient Selection Research/trends Transplantation, Autologous Dewey 617 57 Département de chirurgie 222 false 955 Mécanismes physiopathologiques de l'arthrose 960 Revue médicale suisse 3 120 82bac7a6-5678-454f-8b46-d58e42e3dae5 Article (Published version) Restricted 2007_garavaglia_rev_med_suisse.pdf 3661277 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Implantation de chondrocytes autologues pour les lésions cartilagineuses focales : le point en 2007	Revue médicale suisse			2007	577	0

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Lubowicki, Anne