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English

Quantification of GABAA receptors in the rat brain with [(123)I]Iomazenil SPECT from factor analysis-denoised images

Contributors

Tsartsalis, Stergios; Moulin-Sallanon, Marcelle; Dumas, Noe; Tournier, Benjamin; Ghezzi, Catherine; Charnay, Yves; Ginovart, Nathalie; Millet, Philippe

Published in

Nuclear medicine and biology, vol. 41, no. 2, p. 186-195

Publication date

2014

Abstract

In vivo imaging of GABAA receptors is essential for the comprehension of psychiatric disorders in which the GABAergic system is implicated. Small animal SPECT provides a modality for in vivo imaging of the GABAergic system in rodents using [(123)I]Iomazenil, an antagonist of the GABAA receptor. The goal of this work is to describe and evaluate different quantitative reference tissue methods that enable reliable binding potential (BP) estimations in the rat brain to be obtained.

Keywords

  • Iomazenil
  • SPECT
  • GABAA receptor
  • Benzodiazepine receptor
  • Factor analysis

UNIGE affiliation entities

UNIGE research groups

Funding

Citation (ISO format)

TSARTSALIS, Stergios et al. Quantification of GABAA receptors in the rat brain with [(123)I]Iomazenil SPECT from factor analysis-denoised images. In: Nuclear medicine and biology, 2014, vol. 41, n° 2, p. 186–195. doi: 10.1016/j.nucmedbio.2013.11.008

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0969-8051
793views
699downloads

Technical informations

Creation

17/02/2014 16:46:00

First validation

17/02/2014 16:46:00

Update

13/10/2025 22:58:01

Status update

15/11/2024 15:45:37

Last indexation

03/11/2025 16:24:52
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