Quantification of GABA<sub>A</sub> receptors in the rat brain with [(<sup>123</sup>)I]Iomazenil SPECT from factor analysis-denoised images

Tsartsalis, Stergios; Moulin-Sallanon, Marcelle; Dumas, Noe; Tournier, Benjamin; Ghezzi, Catherine; Charnay, Yves; Ginovart, Nathalie; Millet, Philippe

doi:10.1016/j.nucmedbio.2013.11.008

Scientific article

English

Quantification of GABA_A receptors in the rat brain with [(¹²³)I]Iomazenil SPECT from factor analysis-denoised images

ContributorsTsartsalis, Stergios

; Moulin-Sallanon, Marcelle; Dumas, Noe; Tournier, Benjamin; Ghezzi, Catherine; Charnay, Yves; Ginovart, Nathalie

; Millet, Philippe

Published inNuclear medicine and biology, vol. 41, no. 2, p. 186-195

Publication date2014

Abstract

In vivo imaging of GABAA receptors is essential for the comprehension of psychiatric disorders in which the GABAergic system is implicated. Small animal SPECT provides a modality for in vivo imaging of the GABAergic system in rodents using [(123)I]Iomazenil, an antagonist of the GABAA receptor. The goal of this work is to describe and evaluate different quantitative reference tissue methods that enable reliable binding potential (BP) estimations in the rat brain to be obtained.

Keywords

Iomazenil
SPECT
GABAA receptor
Benzodiazepine receptor
Factor analysis

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de psychiatrie

Research groups

Funding

Swiss National Science Foundation - Brain imaging of 5-HT4 serotonin receptors in experimental models of feeding behaviors [120369]

Citation (ISO format)

TSARTSALIS, Stergios et al. Quantification of GABA_A receptors in the rat brain with [(¹²³)I]Iomazenil SPECT from factor analysis-denoised images. In: Nuclear medicine and biology, 2014, vol. 41, n° 2, p. 186–195. doi: 10.1016/j.nucmedbio.2013.11.008

Article (Published version)

Identifiers

PID : unige:34635
DOI : 10.1016/j.nucmedbio.2013.11.008
PMID : 24405841

Journal ISSN0969-8051

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Quantification of GABAA receptors in the rat brain with [(123)I]Iomazenil SPECT from factor analysis-denoised images

Technical informations

Quantification of GABA_A receptors in the rat brain with [(¹²³)I]Iomazenil SPECT from factor analysis-denoised images