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Quantification of GABAA receptors in the rat brain with [(123)I]Iomazenil SPECT from factor analysis-denoised images

Published inNuclear medicine and biology, vol. 41, no. 2, p. 186-195
Publication date2014
Abstract

In vivo imaging of GABAA receptors is essential for the comprehension of psychiatric disorders in which the GABAergic system is implicated. Small animal SPECT provides a modality for in vivo imaging of the GABAergic system in rodents using [(123)I]Iomazenil, an antagonist of the GABAA receptor. The goal of this work is to describe and evaluate different quantitative reference tissue methods that enable reliable binding potential (BP) estimations in the rat brain to be obtained.

Keywords
  • Iomazenil
  • SPECT
  • GABAA receptor
  • Benzodiazepine receptor
  • Factor analysis
Citation (ISO format)
TSARTSALIS, Stergios et al. Quantification of GABA<sub>A</sub> receptors in the rat brain with [(<sup>123</sup>)I]Iomazenil SPECT from factor analysis-denoised images. In: Nuclear medicine and biology, 2014, vol. 41, n° 2, p. 186–195. doi: 10.1016/j.nucmedbio.2013.11.008
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ISSN of the journal0969-8051
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Creation02/17/2014 4:46:00 PM
First validation02/17/2014 4:46:00 PM
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