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Scientific article
Open access
English

Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

Published inArthritis research & therapy, vol. 3, no. 3, p. 178-182
Publication date2001
Abstract

In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.

Keywords
  • Adult
  • Aged
  • Biological Markers/blood
  • Female
  • Humans
  • Lung/physiopathology
  • Male
  • Middle Aged
  • Peptide Fragments/blood
  • Procollagen/blood
  • Protein Precursors/blood/diagnostic use
  • Respiratory Function Tests
  • Scleroderma, Localized/blood/diagnosis/physiopathology
  • Scleroderma, Systemic/blood/diagnosis/physiopathology
  • Von Willebrand Factor/analysis/diagnostic use
Citation (ISO format)
SCHEJA, A et al. Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma). In: Arthritis research & therapy, 2001, vol. 3, n° 3, p. 178–182.
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Article (Published version)
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Identifiers
ISSN of the journal1478-6354
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127downloads

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