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Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)

Scheja, A
Akesson, A
Geborek, P
Wildt, M
Wollheim, F A
Published in Arthritis Research and Therapy. 2001, vol. 3, no. 3, p. 178-82
Abstract In 44 consecutive patients with systemic sclerosis (SSc), plasma concentrations of von Willebrand factor (vWf) were higher than those of the vWf propeptide, but the propeptide showed less variability within patient subgroups. Higher values of the propeptide were observed in patients with early pulmonary involvement. A closer correlation of the propeptide than of vWf to biochemical markers of activity was also evident. Our results suggest that the propeptide, despite a shorter circulating half-time and lower plasma concentrations than vWf, is more useful in the assessment of disease activity in SSc.
Keywords AdultAgedBiological Markers/bloodFemaleHumansLung/physiopathologyMaleMiddle AgedPeptide Fragments/bloodProcollagen/bloodProtein Precursors/blood/diagnostic useRespiratory Function TestsScleroderma, Localized/blood/diagnosis/physiopathologyScleroderma, Systemic/blood/diagnosis/physiopathologyVon Willebrand Factor/analysis/diagnostic use
PMID: 11299058
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SCHEJA, A et al. Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma). In: Arthritis Research and Therapy, 2001, vol. 3, n° 3, p. 178-82. https://archive-ouverte.unige.ch/unige:34625

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Deposited on : 2014-03-05

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