Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues
Contributeurs/tricesWinzell, Maria Sörhede; Pacini, Giovanni; Wollheim, Claes; Ahrén, Bo
Publié dansDiabetes, vol. 53 Suppl 3, p. S92-96
Date de publication2004
Résumé
Mots-clés
- Animals
- Arginine/pharmacology
- Blood Glucose/metabolism
- Carbachol/pharmacology
- DNA-Binding Proteins/genetics
- Genes, Dominant
- Glucose/pharmacology
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Insulin/analysis/secretion
- Islets of Langerhans/drug effects/physiology/secretion
- Male
- Mice
- Mice, Transgenic
- Mutation
- Nuclear Proteins/genetics
- Palmitic Acid/pharmacology
- Potassium Chloride/pharmacology
- Rats
- Transcription Factors/genetics
Structure d'affiliation
Citation (format ISO)
WINZELL, Maria Sörhede et al. Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues. In: Diabetes, 2004, vol. 53 Suppl 3, p. S92–96. doi: 10.2337/diabetes.53.suppl_3.S92
Fichiers principaux (1)
Article (Published version)
Identifiants
- PID : unige:34543
- DOI : 10.2337/diabetes.53.suppl_3.S92
- PMID : 15561929
ISSN du journal0012-1797