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Title

Expectations and strategies regarding islet transplantation: metabolic data from the GRAGIL 2 trial

Authors
Badet, Lionel
Benhamou, Pierre Y
Milliat-Guittard, Laure
Kessler, Laurence
Penfornis, Alfred
Thivolet, Charles
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Published in Transplantation. 2007, vol. 84, no. 1, p. 89-96
Abstract Whether islet transplantation should be aimed at restoring insulin independence or providing adequate metabolic control is still debated. The GRAGIL2 trial was designed as a phase 1-2 study where primary outcome was the rate of insulin independence, and secondary outcome was the success rate defined by a composite score based upon basal C-peptide, HbA1c, hypoglycemic events, and exogenous insulin needs.
Keywords AdultBlood Glucose/metabolismClinical Trials as TopicDiabetes Mellitus, Type 1/metabolism/surgeryFemaleFollow-Up StudiesHumansHypoglycemia/physiopathologyImmunosuppressive Agents/adverse effects/therapeutic useInsulin/secretionIslets of Langerhans Transplantation/adverse effects/methodsMaleMiddle AgedMulticenter Studies as TopicOptic Nerve Diseases/chemically inducedSeverity of Illness IndexTreatment Outcome
Identifiers
PMID: 17627243
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Structures
Research groups Chirurgie viscérale (104)
La transplantation d'îlots de Langerhans (623)
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BADET, Lionel et al. Expectations and strategies regarding islet transplantation: metabolic data from the GRAGIL 2 trial. In: Transplantation, 2007, vol. 84, n° 1, p. 89-96. https://archive-ouverte.unige.ch/unige:34500

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Deposited on : 2014-02-27

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