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Regulation of Rps6 phosphorylation by TOR complexes in Saccharomyces cerevisiae

Defense Thèse de doctorat : Univ. Genève, 2013 - Sc. 4613 - 2013/11/14
Abstract The Target Of Rapamycin (TOR) pathway is a central regulator of cell growth in response to various environmental and cell intrinsic cues. In this work, we investigated the role of TOR pathway in the regulation of the fate of an mRNA in Saccharomyces cerevisiae. The first part of the thesis work was dedicated to the investigation of how Ccr4, the major deadenylase in budding yeast, is regulated by TOR complex 1, while the second part focused on the regulation of translation by TOR complexes 1 and 2 with a specific interest on the regulation of the phosphorylation of a ribosomal protein, Rps6 in a TOR-dependent manner.
Keywords SignalingKinaseCcr4MRNADeadenylation
URN: urn:nbn:ch:unige-343664
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Research group Groupe Loewith
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YERLIKAYA, Seda. Regulation of Rps6 phosphorylation by TOR complexes in Saccharomyces cerevisiae. Université de Genève. Thèse, 2013. doi: 10.13097/archive-ouverte/unige:34366 https://archive-ouverte.unige.ch/unige:34366

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Deposited on : 2014-02-17

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