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Cancer chemopreventive diterpenes from Salvia corrugata

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Published in Phytochemistry. 2013, vol. 96, p. 257-264
Abstract NMR and NP-HPLC-UV profiling of the exudate of Salvia corrugata revealed that its secondary metabolite composition was largely dominated by α-hydroxy-β-isopropyl-benzoquinone diterpenoids. Among them, four diterpenes not described previously were isolated and identified as fruticulin C (3), 7α-methoxy-19-acetoxy-royleanone (4), 7α,19-diacetoxy-royleanone (5), and 7-dehydroxy-conacytone (7). In addition, the known diterpenes fruticulin A (1), demethyl-fruticulin A (2) and 7α-O-methyl-conacytone (6) were also obtained. The isolated compounds were evaluated for their cancer chemopreventive activity by measuring quinone reductase induction activity and histone deacetylase inhibition. Three compounds (1, 2 and 5) showed promising activity.
Keywords Salvia corrugataDiterpenesAbietaneIcetexaneFruticulin CQuinone reductaseHistone deacetylase
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Research groups Phytochimie et produits naturels bioactifs
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GIACOMELLI, Emanuela et al. Cancer chemopreventive diterpenes from Salvia corrugata. In: Phytochemistry, 2013, vol. 96, p. 257-264. https://archive-ouverte.unige.ch/unige:34040

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Deposited on : 2014-02-03

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