Cancer chemopreventive diterpenes from Salvia corrugata

Giacomelli, Emanuela; Bertrand, Samuel; Nievergelt-Meier, Andreas; Zwick, Vincent; Simoes Avello, Claudia; Marcourt, Laurence; Rivara-Minten, Elisabeth; Cuendet, Muriel; Bisio, Angela; Wolfender, Jean-Luc

doi:10.1016/j.phytochem.2013.09.011

Scientific article

English

Cancer chemopreventive diterpenes from Salvia corrugata

Contributors

Giacomelli, Emanuela; Bertrand, Samuel; Nievergelt-Meier, Andreas; Zwick, Vincent; Simoes Avello, Claudia; Marcourt, Laurence; Rivara-Minten, Elisabeth; Cuendet, Muriel

; Bisio, Angela; Wolfender, Jean-Luc

Published in

Phytochemistry, vol. 96, p. 257-264

Publication date

2013

Abstract

NMR and NP-HPLC-UV profiling of the exudate of Salvia corrugata revealed that its secondary metabolite composition was largely dominated by α-hydroxy-β-isopropyl-benzoquinone diterpenoids. Among them, four diterpenes not described previously were isolated and identified as fruticulin C (3), 7α-methoxy-19-acetoxy-royleanone (4), 7α,19-diacetoxy-royleanone (5), and 7-dehydroxy-conacytone (7). In addition, the known diterpenes fruticulin A (1), demethyl-fruticulin A (2) and 7α-O-methyl-conacytone (6) were also obtained. The isolated compounds were evaluated for their cancer chemopreventive activity by measuring quinone reductase induction activity and histone deacetylase inhibition. Three compounds (1, 2 and 5) showed promising activity.

Keywords

Salvia corrugata
Diterpenes
Abietane
Icetexane
Fruticulin C
Quinone reductase
Histone deacetylase

UNIGE affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

UNIGE research groups

Citation (ISO format)

GIACOMELLI, Emanuela et al. Cancer chemopreventive diterpenes from Salvia corrugata. In: Phytochemistry, 2013, vol. 96, p. 257–264. doi: 10.1016/j.phytochem.2013.09.011

Article (Published version)

Identifiers

PID : unige:34040
DOI : 10.1016/j.phytochem.2013.09.011

Additional URL for this publication

http://linkinghub.elsevier.com/retrieve/pii/S003194221300349X

Journal ISSN

0031-9422

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Cancer chemopreventive diterpenes from Salvia corrugata

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Published in

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Abstract

Keywords

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

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Creation

First validation

Update

Status update

Last indexation