Cancer chemopreventive diterpenes from Salvia corrugata

Article Article scientifique Article Cancer chemopreventive diterpenes from Salvia corrugata eng 2013 author Giacomelli Emanuela 743452 author Bertrand Samuel 735515 author Nievergelt-Meier Andreas 732605 author Zwick Vincent 595034 author Simoes Avello Claudia 630402 author Marcourt Laurence 729234 author Rivara-Minten Elisabeth 23985 author Cuendet Muriel 0000-0002-1523-1907 686755 author Bisio Angela author Wolfender Jean-Luc 135649 257-264 10.1016/j.phytochem.2013.09.011 0031-9422 http://linkinghub.elsevier.com/retrieve/pii/S003194221300349X NMR and NP-HPLC-UV profiling of the exudate of Salvia corrugata revealed that its secondary metabolite composition was largely dominated by α-hydroxy-β-isopropyl-benzoquinone diterpenoids. Among them, four diterpenes not described previously were isolated and identified as fruticulin C (3), 7α-methoxy-19-acetoxy-royleanone (4), 7α,19-diacetoxy-royleanone (5), and 7-dehydroxy-conacytone (7). In addition, the known diterpenes fruticulin A (1), demethyl-fruticulin A (2) and 7α-O-methyl-conacytone (6) were also obtained. The isolated compounds were evaluated for their cancer chemopreventive activity by measuring quinone reductase induction activity and histone deacetylase inhibition. Three compounds (1, 2 and 5) showed promising activity. Salvia corrugata Diterpenes Abietane Icetexane Fruticulin C Quinone reductase Histone deacetylase Dewey 615 31 Section des sciences pharmaceutiques 17 false 884 Pharmacognosie 882 Phytochimie et produits naturels bioactifs Phytochemistry 96 9dd4c2ee-8750-433f-9654-61cdb4dfbcd0 Article (Published version) Restricted 1-s2.0-S003194221300349X-main.pdf 773898 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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Cancer chemopreventive diterpenes from Salvia corrugata	Phytochemistry			2013	737	4

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Giacomelli, Emanuela