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Natural HLA class I ligands from glioblastoma: extending the options for immunotherapy

Neidert, Marian Christoph
Schoor, Oliver
Trautwein, Claudia
Trautwein, Nico
Christ, Lisa
Melms, Arthur
Honegger, Jürgen
Rammensee, Hans-Georg
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Published in Journal of Neuro-Oncology. 2013, vol. 111, no. 3, p. 285-94
Abstract Glioblastoma multiforme is the most frequent and most malignant primary brain tumor with poor prognosis despite surgical removal and radio-chemotherapy. In this setting, immunotherapeutical strategies have great potential, but the reported repertoire of tumor associated antigens is only for HLA-A 02 positive tumors. We describe the first analysis of HLA-peptide presentation patterns in HLA-A 02 negative glioma tissue combined with gene expression profiling of the tumor samples by oligonucleotide microarrays. We identified numerous candidate peptides for immunotherapy. These are peptides derived from proteins with a well-described role in glioma tumor biology and suitable gene expression profiles such as PTPRZ1, EGFR, SEC61G and TNC. Information obtained from complementary analyses of HLA-A 02 negative tumors not only contributes to the discovery of novel shared glioma antigens, but most importantly provides the opportunity to tailor a patient-individual cocktail of tumor-associated peptides for a personalized, targeted immunotherapeutic approach in HLA-A 02 negative patients.
Keywords Brain Neoplasms/classification/metabolism/pathologyGene Expression Regulation, Neoplastic/physiologyGlial Fibrillary Acidic Protein/metabolismGlioblastoma/classification/metabolism/pathologyHLA Antigens/metabolismHumansLigandsMembrane Proteins/metabolismPeptides/metabolismReceptor, Epidermal Growth Factor/metabolismReceptor-Like Protein Tyrosine Phosphatases, Class 5/metabolismTandem Mass Spectrometry
PMID: 23263746
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Research group Immunothérapie des cancers (42)
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NEIDERT, Marian Christoph et al. Natural HLA class I ligands from glioblastoma: extending the options for immunotherapy. In: Journal of Neuro-Oncology, 2013, vol. 111, n° 3, p. 285-94. https://archive-ouverte.unige.ch/unige:33805

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Deposited on : 2014-01-28

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