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Synergy between CD8 T cells and Th1 or Th2 polarised CD4 T cells for adoptive immunotherapy of brain tumours

Loh, Jacelyn M S
Maroun, Céline Yacoub
Published in PLOS ONE. 2013, vol. 8, no. 5, p. e63933
Abstract The feasibility of cancer immunotherapy mediated by T lymphocytes is now a clinical reality. Indeed, many tumour associated antigens have been identified for cytotoxic CD8 T cells, which are believed to be key mediators of tumour rejection. However, for aggressive malignancies in specialised anatomic sites such as the brain, a limiting factor is suboptimal tumour infiltration by CD8 T cells. Here we take advantage of recent advances in T cell biology to differentially polarise CD4 T cells in order to explore their capacity to enhance immunotherapy. We used an adoptive cell therapy approach to work with clonal T cell populations of defined specificity. Th1 CD4 T cells preferentially homed to and accumulated within intracranial tumours compared with Th2 CD4 T cells. Moreover, tumour-antigen specific Th1 CD4 T cells enhanced CD8 T cell recruitment and function within the brain tumour bed. Survival of mice bearing intracranial tumours was significantly prolonged when CD4 and CD8 T cells were co-transferred. These results should encourage further definition of tumour antigens recognised by CD4 T cells, and exploitation of both CD4 and CD8 T cell subsets to optimise T cell therapy of cancer.
PMID: 23717511
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Article (Published version) (2.7 MB) - public document Free access
Research groups Immunothérapie des cancers (42)
Immunobiologie des tumeurs du cerveau (669)
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HOEPNER, Sabine et al. Synergy between CD8 T cells and Th1 or Th2 polarised CD4 T cells for adoptive immunotherapy of brain tumours. In: PLOS ONE, 2013, vol. 8, n° 5, p. e63933. doi: 10.1371/journal.pone.0063933 https://archive-ouverte.unige.ch/unige:33769

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Deposited on : 2014-01-28

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