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DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

ContributorsHall, Elin; Dayeh, Tasnim; Kirkpatrick, Clare; Wollheim, Claes; Dekker Nitert, Marloes; Ling, Charlotte
Published inBMC medical genetics, vol. 14, 76
Publication date2013
Abstract

Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by differential DNA methylation of GLP1R in pancreatic islets of type 2 diabetic patients.

Keywords
  • Aged
  • Body Mass Index
  • CpG Islands
  • DNA (Cytosine-5-)-Methyltransferase/genetics
  • DNA Methylation
  • Diabetes Mellitus, Type 2/genetics
  • Female
  • Glucagon-Like Peptide 1/metabolism
  • Glucagon-Secreting Cells/metabolism
  • Hemoglobin A, Glycosylated/genetics
  • Humans
  • Insulin/secretion
  • Insulin-Secreting Cells/metabolism
  • Islets of Langerhans/cytology/metabolism
  • Male
  • Methyl-CpG-Binding Protein 2/genetics
  • Middle Aged
  • Receptors, Glucagon/genetics/metabolism
  • Transcription Initiation Site
Affiliation
Citation (ISO format)
HALL, Elin et al. DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets. In: BMC medical genetics, 2013, vol. 14, p. 76. doi: 10.1186/1471-2350-14-76
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1471-2350
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485downloads

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