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Title

DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets

Authors
Hall, Elin
Dayeh, Tasnim
Dekker Nitert, Marloes
Ling, Charlotte
Published in BMC Medical Genetics. 2013, vol. 14, p. 76
Abstract Insulin secretion is enhanced upon the binding of Glucagon-like peptide-1 (GLP-1) to its receptor (GLP1R) in pancreatic β cells. Although a reduced expression of GLP1R in pancreatic islets from type 2 diabetic patients and hyperglycaemic rats has been established, it is still unknown if this is caused by differential DNA methylation of GLP1R in pancreatic islets of type 2 diabetic patients.
Keywords AgedBody Mass IndexCpG IslandsDNA (Cytosine-5-)-Methyltransferase/geneticsDNA MethylationDiabetes Mellitus, Type 2/geneticsFemaleGlucagon-Like Peptide 1/metabolismGlucagon-Secreting Cells/metabolismHemoglobin A, Glycosylated/geneticsHumansInsulin/secretionInsulin-Secreting Cells/metabolismIslets of Langerhans/cytology/metabolismMaleMethyl-CpG-Binding Protein 2/geneticsMiddle AgedReceptors, Glucagon/genetics/metabolismTranscription Initiation Site
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PMID: 23879380
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HALL, Elin et al. DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets. In: BMC Medical Genetics, 2013, vol. 14, p. 76. https://archive-ouverte.unige.ch/unige:33558

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Deposited on : 2014-01-22

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